The biology of cutaneous neurofibromas

Consensus recommendations for setting research priorities

Jean Philippe Brosseau, Dominique C. Pichard, Eric H. Legius, Pierre Wolkenstein, Robert M. Lavker, Jaishri O. Blakeley, Vincent M. Riccardi, Sharad K. Verma, Isaac Brownell, Lu Q Le

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: A group of experts in dermatology, genetics, neuroscience, and regenerative medicine collaborated to summarize current knowledge on the defined factors contributing to cutaneous neurofibroma (cNF) development and to provide consensus recommendations for future research priorities to gain an improved understanding of the biology of cNF. METHODS: The group members reviewed published and unpublished data on cNF and related diseases via literature search, defined a set of key topic areas deemed critical in cNF pathogenesis, and developed recommendations in a series of consensus meetings. RESULTS: Five specific topic areas were identified as being relevant to providing an enhanced understanding of the biology of cNF: (1) defining the human cells of origin; (2) understanding the role of the microenvironment, focusing on neurons, mast cells, and fibroblasts; (3) defining the genetic and molecular differences between the cNFs, focusing on size and number; (4) understanding if sex hormones are critical for cNF development or progression; and (5) identifying challenges in establishing in vitro and in vivo models representing human cNF. CONCLUSIONS: The complexity of cNF biology stems from its heterogeneity at multiple levels including genetic, spatial involvement, temporal development, and cellular composition. We propose a unified working model for cNF that builds a framework to address the key questions about cNF that, when answered, will provide the necessary understanding of cNF biology to allow meaningful development of therapies.

Original languageEnglish (US)
Pages (from-to)S14-S20
JournalNeurology
Volume91
Issue number2
DOIs
StatePublished - Jul 10 2018

Fingerprint

Neurofibroma
Skin
Research
Regenerative Medicine
Gonadal Steroid Hormones
Neurosciences
Dermatology
Mast Cells
Molecular Biology
Fibroblasts

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Brosseau, J. P., Pichard, D. C., Legius, E. H., Wolkenstein, P., Lavker, R. M., Blakeley, J. O., ... Le, L. Q. (2018). The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities. Neurology, 91(2), S14-S20. https://doi.org/10.1212/WNL.0000000000005788

The biology of cutaneous neurofibromas : Consensus recommendations for setting research priorities. / Brosseau, Jean Philippe; Pichard, Dominique C.; Legius, Eric H.; Wolkenstein, Pierre; Lavker, Robert M.; Blakeley, Jaishri O.; Riccardi, Vincent M.; Verma, Sharad K.; Brownell, Isaac; Le, Lu Q.

In: Neurology, Vol. 91, No. 2, 10.07.2018, p. S14-S20.

Research output: Contribution to journalArticle

Brosseau, JP, Pichard, DC, Legius, EH, Wolkenstein, P, Lavker, RM, Blakeley, JO, Riccardi, VM, Verma, SK, Brownell, I & Le, LQ 2018, 'The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities', Neurology, vol. 91, no. 2, pp. S14-S20. https://doi.org/10.1212/WNL.0000000000005788
Brosseau JP, Pichard DC, Legius EH, Wolkenstein P, Lavker RM, Blakeley JO et al. The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities. Neurology. 2018 Jul 10;91(2):S14-S20. https://doi.org/10.1212/WNL.0000000000005788
Brosseau, Jean Philippe ; Pichard, Dominique C. ; Legius, Eric H. ; Wolkenstein, Pierre ; Lavker, Robert M. ; Blakeley, Jaishri O. ; Riccardi, Vincent M. ; Verma, Sharad K. ; Brownell, Isaac ; Le, Lu Q. / The biology of cutaneous neurofibromas : Consensus recommendations for setting research priorities. In: Neurology. 2018 ; Vol. 91, No. 2. pp. S14-S20.
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