The biology of hematopoietic stem cells

Sean J. Morrison, Nobuko Uchida, Irving L. Weissman

Research output: Contribution to journalReview article

593 Scopus citations

Abstract

Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects observed after bone marrow transplantation. The subsets of HSC that give rise to short-term vs long-term multilineage reconstitution can be separated by phenotype, demonstrating that the fates of HSC are intrinsically determined. Here we review the ontogeny and biology of HSC, their expression of fate-determining genes, and the clinical importance of HSC for transplantation and gene therapy.

Original languageEnglish (US)
Pages (from-to)35-71
Number of pages37
JournalAnnual Review of Cell and Developmental Biology
Volume11
DOIs
StatePublished - Jan 1 1995

Keywords

  • differentiation
  • mobilization
  • multipotent progenitor
  • self-renewal
  • transplantation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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