Abstract
The understanding of lung cancer pathogenesis is rapidly growing and needs to be translated into clinical practice. Molecular screening approaches will be combined with CT scans to detect premalignant lesions and early-stage cancers in high-risk groups for lung cancer and to monitor the efficacy of chemoprevention trials. New treatment approaches, such as gene therapy, monoclonal antibodies against growth factors and receptors, angiogenesis inhibitors, vaccines, apoptosis modulators, and new drugs targeted at these abnormal pathways, will be tested and, if effective, included in future multimodality treatment strategies of lung cancer. All these approaches will hopefully lead to earlier diagnosis and more efficient treatment of lung cancer, resulting in a better prognosis of this still mostly lethal disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 691-708 |
| Number of pages | 18 |
| Journal | Chest Surgery Clinics of North America |
| Volume | 10 |
| Issue number | 4 |
| State | Published - 2000 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
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The biology of lung cancer including potential clinical applications. / Zochbauer-Muller, S.; Minna, J. D.
In: Chest Surgery Clinics of North America, Vol. 10, No. 4, 2000, p. 691-708.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The biology of lung cancer including potential clinical applications
AU - Zochbauer-Muller, S.
AU - Minna, J. D.
PY - 2000
Y1 - 2000
N2 - The understanding of lung cancer pathogenesis is rapidly growing and needs to be translated into clinical practice. Molecular screening approaches will be combined with CT scans to detect premalignant lesions and early-stage cancers in high-risk groups for lung cancer and to monitor the efficacy of chemoprevention trials. New treatment approaches, such as gene therapy, monoclonal antibodies against growth factors and receptors, angiogenesis inhibitors, vaccines, apoptosis modulators, and new drugs targeted at these abnormal pathways, will be tested and, if effective, included in future multimodality treatment strategies of lung cancer. All these approaches will hopefully lead to earlier diagnosis and more efficient treatment of lung cancer, resulting in a better prognosis of this still mostly lethal disease.
AB - The understanding of lung cancer pathogenesis is rapidly growing and needs to be translated into clinical practice. Molecular screening approaches will be combined with CT scans to detect premalignant lesions and early-stage cancers in high-risk groups for lung cancer and to monitor the efficacy of chemoprevention trials. New treatment approaches, such as gene therapy, monoclonal antibodies against growth factors and receptors, angiogenesis inhibitors, vaccines, apoptosis modulators, and new drugs targeted at these abnormal pathways, will be tested and, if effective, included in future multimodality treatment strategies of lung cancer. All these approaches will hopefully lead to earlier diagnosis and more efficient treatment of lung cancer, resulting in a better prognosis of this still mostly lethal disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033758496&partnerID=8YFLogxK
M3 - Article
C2 - 11091920
AN - SCOPUS:0033758496
VL - 10
SP - 691
EP - 708
JO - Thoracic Surgery Clinics
JF - Thoracic Surgery Clinics
SN - 1547-4127
IS - 4
ER -