The biology of perisynaptic (terminal) Schwann cells

Chien Ping Ko, Yoshie Sugiura, Zhihua Feng

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

There are four classes of Schwann cells in the mature vertebrate nervous system: (1) myelinating Schwann cells, which wrap around large-diameter axons including motor axons; (2) non-myelinating Schwann cells, which associate with small-diameter axons of many sensory and all postganglionic sympathetic neurons; (3) satellite cells of peripheral ganglia; and (4) non-myelinating perisynaptic Schwann cells (PSCs), also known as terminal Schwann cells, which cap the nerve terminal at the neuromuscular junction (NMJ) (Corfas et al. 2004). While the role of motor and sensory axon-associated Schwann cells in saltatory conduction has been well-acknowledged and characterised, relatively little is known about the role of the synapse-associated Schwann cells. However, in the past decade, there has been widespread interest in unraveling the role of Schwann cells in peripheral synapses as well as the role of astrocytes in central synapses. Extensive studies on synapse-neuroglial interactions in both the peripheral nervous system (PNS) and central nervous system (CNS) have led to the concept of the tripartite synapse (Araque et al. 1999; Volterra et al. 2002; Kettenmann and Ransom 2005). The emerging concept suggests that neuroglia cells are active and essential participants in modulating synaptic function, promoting synapse repair and development and stabilising synapses. Thus, it is no longer tenable to view the neurochemical synapse as a synaptic contact made of only the presynaptic nerve terminal and the postsynaptic target, without taking into consideration the multiple active roles of the third element, neuroglia, specifically here the PSCs.

Original languageEnglish (US)
Title of host publicationThe Biology of Schwann Cells: Development, Differentiation and Immunomodulation
PublisherCambridge University Press
Pages72-99
Number of pages28
ISBN (Electronic)9780511541605
ISBN (Print)0521850207, 9780521850209
DOIs
StatePublished - Jan 1 2007

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Schwann Cells
Synapses
Axons
Neuroglia
Neuromuscular Junction
Presynaptic Terminals
Peripheral Nervous System
Ganglia
Astrocytes
Nervous System
Vertebrates
Central Nervous System
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ko, C. P., Sugiura, Y., & Feng, Z. (2007). The biology of perisynaptic (terminal) Schwann cells. In The Biology of Schwann Cells: Development, Differentiation and Immunomodulation (pp. 72-99). Cambridge University Press. https://doi.org/10.1017/CBO9780511541605.006

The biology of perisynaptic (terminal) Schwann cells. / Ko, Chien Ping; Sugiura, Yoshie; Feng, Zhihua.

The Biology of Schwann Cells: Development, Differentiation and Immunomodulation. Cambridge University Press, 2007. p. 72-99.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ko, CP, Sugiura, Y & Feng, Z 2007, The biology of perisynaptic (terminal) Schwann cells. in The Biology of Schwann Cells: Development, Differentiation and Immunomodulation. Cambridge University Press, pp. 72-99. https://doi.org/10.1017/CBO9780511541605.006
Ko CP, Sugiura Y, Feng Z. The biology of perisynaptic (terminal) Schwann cells. In The Biology of Schwann Cells: Development, Differentiation and Immunomodulation. Cambridge University Press. 2007. p. 72-99 https://doi.org/10.1017/CBO9780511541605.006
Ko, Chien Ping ; Sugiura, Yoshie ; Feng, Zhihua. / The biology of perisynaptic (terminal) Schwann cells. The Biology of Schwann Cells: Development, Differentiation and Immunomodulation. Cambridge University Press, 2007. pp. 72-99
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