The Body-wide Transcriptome Landscape of Disease Models

Satoshi Kozawa, Ryosuke Ueda, Kyoji Urayama, Fumihiko Sagawa, Satsuki Endo, Kazuhiro Shiizaki, Hiroshi Kurosu, Glicia Maria de Almeida, Sharif M. Hasan, Kiyokazu Nakazato, Shinji Ozaki, Yoshinori Yamashita, Makoto Kuro-o, Thomas N. Sato

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, kidney diseases, cancer, and pre-mature aging. Using such datasets, we find (1)differential gene expression in diverse organs across all models; (2)skin as a disease-sensor organ represented by disease-specific activities of putative gene-expression network; (3)a bone-skin cross talk mediated by a bone-derived hormone, FGF23, in response to dysregulated phosphate homeostasis, a known risk-factor for kidney diseases; (4)candidates for the signature activities of many more putative inter-organ cross talk for diseases; and (5)a cross-species map illustrating organ-to-organ and model-to-disease relationships between human and mouse. These findings demonstrate the usefulness and the potential of such body-wide datasets encompassing mouse models of diverse disease types as a resource in biological and medical sciences. Furthermore, the findings described herein could be exploited for designing disease diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)238-268
Number of pages31
JournalFood Science and Human Wellness
Volume2
DOIs
Publication statusPublished - Apr 27 2018
Externally publishedYes

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Keywords

  • Experimental Models in Systems Biology
  • Gene Network
  • Transcriptomics

ASJC Scopus subject areas

  • Food Science
  • General

Cite this

Kozawa, S., Ueda, R., Urayama, K., Sagawa, F., Endo, S., Shiizaki, K., ... Sato, T. N. (2018). The Body-wide Transcriptome Landscape of Disease Models. Food Science and Human Wellness, 2, 238-268. https://doi.org/10.1016/j.isci.2018.03.014