@article{9f582ecbb53345a783e1a45089c28825,
title = "The Body-wide Transcriptome Landscape of Disease Models",
abstract = "Gene",
keywords = "Experimental Models in Systems Biology, Gene Network, Transcriptomics",
author = "Satoshi Kozawa and Ryosuke Ueda and Kyoji Urayama and Fumihiko Sagawa and Satsuki Endo and Kazuhiro Shiizaki and Hiroshi Kurosu and {Maria de Almeida}, Glicia and Hasan, {Sharif M.} and Kiyokazu Nakazato and Shinji Ozaki and Yoshinori Yamashita and Makoto Kuro-o and Sato, {Thomas N.}",
note = "Funding Information: We thank T. Ninomiya, T. Kuroda, and H. Anabuki for technical assistance; R. Takahashi and E. Kojima for administrative assistance; and T. Morie for managing the laboratory's daily operations. M.K., K.S., and H.K. thank K. Akiyama for his preparation of mouse organs from CKD models. J.H. Neale and S. Kawaoka read the initial draft versions and provided critical and constructive comments on the manuscript. We are also grateful to the Sato laboratory members for advice and discussion throughout the course of this work. This work was supported by JST ERATO Grant Number JPMJER1303 (T.N.S.), JSPS KAKENHI S Grant Number 22229007 (T.N.S.), AMED Grant Number JP17gm0610012 (M.K.), Society for the Promotion of Science Grant Number 16H05302 & 16K15470 (M.K.). Funding Information: We thank T. Ninomiya, T. Kuroda, and H. Anabuki for technical assistance; R. Takahashi and E. Kojima for administrative assistance; and T. Morie for managing the laboratory's daily operations. M.K. K.S. and H.K. thank K. Akiyama for his preparation of mouse organs from CKD models. J.H. Neale and S. Kawaoka read the initial draft versions and provided critical and constructive comments on the manuscript. We are also grateful to the Sato laboratory members for advice and discussion throughout the course of this work. This work was supported by JST ERATO Grant Number JPMJER1303 (T.N.S.), JSPS KAKENHI S Grant Number 22229007 (T.N.S.), AMED Grant Number JP17gm0610012 (M.K.), Society for the Promotion of Science Grant Number 16H05302 & 16K15470 (M.K.). T.N.S. conceived the idea of the project, designed the overall experiments and in silico analyses and supervised the overall research project. S.K. performed the in silico analyses. R.U. and K.U. contributed to designing the experiments and performed the experiments. F.S. S.E. G.M.A. S.M.H. and K.N. contributed to the experiments. M.K. brought up the idea of using CKD mouse models for the study and contributed to the design of the experiments using the CKD mouse model. M.K. K.S. and H.K. developed the CKD mouse model and collected the organs from this model. Y.Y. and S.O. supervised and coordinated the clinical research and collected human tissue biopsies. T.N.S. S.K. R.U. and K.U. wrote the manuscript. T.N.S. is the inventor of several patents filed on aspects of the work presented herein and is the founder of and holds shares of Karydo TherapeutiX, Inc. which has exclusive rights to these patents. F.S. S.E. G.M.A. S.M.H. and K.N. are employees of Karydo TherapeutiX, Inc. Other authors declare no competing financial interests. Publisher Copyright: {\textcopyright} 2018 The Author(s)",
year = "2018",
month = apr,
day = "27",
doi = "10.1016/j.isci.2018.03.014",
language = "English (US)",
volume = "2",
pages = "238--268",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
}