The BTB-ZF transcription factors

Owen M. Siggs; Bruce Beutler

doi:10.4161/cc.21277

The BTB-ZF transcription factors

Owen M. Siggs, Bruce Beutler

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

Original language	English (US)
Pages (from-to)	3358-3369
Number of pages	12
Journal	Cell Cycle
Volume	11
Issue number	18
DOIs	https://doi.org/10.4161/cc.21277
State	Published - Sep 15 2012

Keywords

BTB
Hematopoiesis
Lymphoma
Lymphopoiesis
Zinc finger

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.4161/cc.21277

Cite this

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title = "The BTB-ZF transcription factors",

abstract = "The BTB-ZF (broad-complex, tramtrack and bric-{\`a}-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.",

keywords = "BTB, Hematopoiesis, Lymphoma, Lymphopoiesis, Zinc finger",

author = "Siggs, {Owen M.} and Bruce Beutler",

note = "Funding Information: We thank Vickie Webster for her expert assistance with figures and Anne Murray for proofreading and preparation of the phylogenetic tree. We also apologize to those authors whose work could not be cited within our limitations. This work was supported by BAA-NIH-NIAID-DAIT and The Bill and Melinda Gates Foundation.",

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AU - Beutler, Bruce

N1 - Funding Information: We thank Vickie Webster for her expert assistance with figures and Anne Murray for proofreading and preparation of the phylogenetic tree. We also apologize to those authors whose work could not be cited within our limitations. This work was supported by BAA-NIH-NIAID-DAIT and The Bill and Melinda Gates Foundation.

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N2 - The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

AB - The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

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KW - Lymphoma

KW - Lymphopoiesis

KW - Zinc finger

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The BTB-ZF transcription factors

Abstract

Keywords

ASJC Scopus subject areas

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