Abstract
Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor pairs and two additional signal receptors, all of which contribute to virulence. We show that B. mallei produces N-3-hydroxyoctanoyl HSL (3OHC8-HSL) but a bmaI3 mutant does not. Recombinant Escherichia coli expressing BmaI3 produces hydroxylated acyl-HSLs, with 3OHC8-HSL being the most abundant compound. In recombinant E. coli, BmaR3 responds to 3OHC8-HSL but not to other acyl-HSLs. These data indicate that the signal for BmaR3-BmaI3 quorum sensing is 3OHC8-HSL.
Original language | English (US) |
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Pages (from-to) | 5137-5141 |
Number of pages | 5 |
Journal | Journal of bacteriology |
Volume | 190 |
Issue number | 14 |
DOIs | |
State | Published - Jul 2008 |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology