The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs

Morgan Tucker, Matt Sieber, Mary Morphew, Min Han

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The homeobox-containing aristaless-related protein ARX has been directly linked to the development of a number of human disorders involving mental retardation and epilepsy and clearly plays a critical role in development of the vertebrate central nervous system. In this work, we investigate the role of ALR-1, the Caenorhabditis elegans aristaless orthologue, in amphid sensory function. Our studies indicate that ALR-1 is required for maintenance of the amphid organ structure throughout larval development. Mutant analysis indicates a progressive loss in the amphid neurons' ability to fill with lipophilic dyes as well as a declining chemotactic response. The degeneration in amphid function corresponds with a failure of the glial-like amphid socket cell to maintain its specific cell shape and cell-cell contacts. Consistent with ALR-1 expression within the amphid socket cell, our results indicate a cell autonomous role for ALR-1 in maintaining cell shape. Furthermore, we demonstrate a role for ALR-1 in the proper morphogenesis of the anterior hypodermis. Genetic interaction tests also suggest that ALR-1 may function cooperatively with the cell adhesion processes in maintaining the amphid sensory organs.

Original languageEnglish (US)
Pages (from-to)4695-4704
Number of pages10
JournalMolecular Biology of the Cell
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2005

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Caenorhabditis elegans
Cell Shape
Aptitude
Homeobox Genes
Subcutaneous Tissue
Morphogenesis
Cell Adhesion
Neuroglia
Intellectual Disability
Vertebrates
Epilepsy
Coloring Agents
Central Nervous System
Maintenance
Neurons
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs. / Tucker, Morgan; Sieber, Matt; Morphew, Mary; Han, Min.

In: Molecular Biology of the Cell, Vol. 16, No. 10, 01.10.2005, p. 4695-4704.

Research output: Contribution to journalArticle

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