The calcium deficiency hypothesis of hypertension: A critique

Norman M Kaplan, R. B. Meese

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Primary (essential) hypertension has recently been related to calcium deficiency, rather than excess. The evidence used to support this hypothesis includes surveys showing lesser dietary intake of calcium, lower levels of ionized calcium in the blood, and reduction of blood pressure with calcium supplements. This critique examines each of these points and the theoretical construct used to explain the hypothesis. We conclude that the theoretical construct is based on the use of only a portion of available experimental data and the clinical evidence remains inconclusive. Until the hypothesis is supported further, calcium deficiency should not be accepted as a mechanism responsible for hypertension and calcium supplements should be used with caution.

Original languageEnglish (US)
Pages (from-to)947-955
Number of pages9
JournalAnnals of Internal Medicine
Volume105
Issue number6
StatePublished - 1986

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Hypertension
Calcium
Dietary Calcium
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kaplan, N. M., & Meese, R. B. (1986). The calcium deficiency hypothesis of hypertension: A critique. Annals of Internal Medicine, 105(6), 947-955.

The calcium deficiency hypothesis of hypertension : A critique. / Kaplan, Norman M; Meese, R. B.

In: Annals of Internal Medicine, Vol. 105, No. 6, 1986, p. 947-955.

Research output: Contribution to journalArticle

Kaplan, NM & Meese, RB 1986, 'The calcium deficiency hypothesis of hypertension: A critique', Annals of Internal Medicine, vol. 105, no. 6, pp. 947-955.
Kaplan, Norman M ; Meese, R. B. / The calcium deficiency hypothesis of hypertension : A critique. In: Annals of Internal Medicine. 1986 ; Vol. 105, No. 6. pp. 947-955.
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