Abstract

Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus supplying enhanced mobility during epithelial–mesenchymal transition (EMT) induced by transforming growth factor β (TGF-β1) (Fig. 1).

Original languageEnglish (US)
Article numbere981994
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Fingerprint

Lipogenesis
Transforming Growth Factors
Cell Division
Energy Metabolism
Neoplasms
Grid Cells
Cellular Reprogramming

Keywords

  • Epithelial-to-Mesenchymal Transition
  • fatty acid synthase
  • lipogenesis
  • metastasis
  • transforming growth factor beta 1 (TGFβ1)

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

Cite this

The cancer cell ‘energy grid’ : TGF-β1 signaling coordinates metabolism for migration. / Jiang, Lei; Deberardinis, Ralph; Boothman, David A.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e981994, 03.07.2015.

Research output: Contribution to journalComment/debate

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