The casein kinase I family: Roles in morphogenesis

Renée M. McKay, John M. Peters, Jonathan M. Graff

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Wnt signals play important roles in development and oncogenesis and are transduced through at least two pathways: a canonical β-catenin-dependent and a β-catenin-independent cascade. Casein kinase I (CKI) is required in both invertebrates and vertebrates to transduce canonical Wnt signals. However, its role in the β-catenin-independent pathway was unknown. During vertebrate embryogenesis, the β-catenin-independent cascade is thought to control cell movements and has been postulated to be analogous to the Drosophila planar cell polarity pathway, which signals through the JNK cascade. Here, we report that blocking CKI function inhibits embryonic morphogenesis and activates JNK in cell lines. These studies suggest that CKI might also act in the β-catenin-independent pathway and indicate a role for CKI during convergence extension in early vertebrate development.

Original languageEnglish (US)
Pages (from-to)378-387
Number of pages10
JournalDevelopmental Biology
Volume235
Issue number2
DOIs
StatePublished - Jul 15 2001

Keywords

  • Casein Kinase I
  • Dishevelled
  • JNK
  • Morphogenesis
  • Planar cell polarity
  • Wnt

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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