The cell biology of fat expansion

Joseph M. Rutkowski, Jennifer H. Stern, Philipp E. Scherer

Research output: Contribution to journalReview article

228 Scopus citations


Adipose tissue is a complex, multicellular organ that profoundly influences the function of nearly all other organ systems through its diverse metabolite and adipokine secretome. Adipocytes are the primary cell type of adipose tissue and play a key role in maintaining energy homeostasis. The efficiency with which adipose tissue responds to whole-body energetic demands reflects the ability of adipocytes to adapt to an altered nutrient environment, and has profound systemic implications. Deciphering adipocyte cell biology is an important component of understanding how the aberrant physiology of expanding adipose tissue contributes to the metabolic dysregulation associated with obesity.

Original languageEnglish (US)
Pages (from-to)501-512
Number of pages12
JournalJournal of Cell Biology
Issue number5
StatePublished - Jan 1 2015


ASJC Scopus subject areas

  • Cell Biology

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