The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET

William E. Klunk, Robert A. Koeppe, Julie C. Price, Tammie L. Benzinger, Michael D. Devous, William J. Jagust, Keith A. Johnson, Chester A. Mathis, Davneet Minhas, Michael J. Pontecorvo, Christopher C. Rowe, Daniel M. Skovronsky, Mark A. Mintun

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

Original languageEnglish (US)
Pages (from-to)1-15.e4
JournalAlzheimer's and Dementia
Volume11
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Amyloid Plaques
Amyloid
Outcome Assessment (Health Care)
Positron-Emission Tomography
Alzheimer Disease

Keywords

  • Amyloid imaging
  • Centiloid scale
  • Pittsburgh compound B
  • Positron emission tomography
  • Standardize

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Klunk, W. E., Koeppe, R. A., Price, J. C., Benzinger, T. L., Devous, M. D., Jagust, W. J., ... Mintun, M. A. (2015). The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET. Alzheimer's and Dementia, 11(1), 1-15.e4. https://doi.org/10.1016/j.jalz.2014.07.003

The Centiloid project : Standardizing quantitative amyloid plaque estimation by PET. / Klunk, William E.; Koeppe, Robert A.; Price, Julie C.; Benzinger, Tammie L.; Devous, Michael D.; Jagust, William J.; Johnson, Keith A.; Mathis, Chester A.; Minhas, Davneet; Pontecorvo, Michael J.; Rowe, Christopher C.; Skovronsky, Daniel M.; Mintun, Mark A.

In: Alzheimer's and Dementia, Vol. 11, No. 1, 2015, p. 1-15.e4.

Research output: Contribution to journalArticle

Klunk, WE, Koeppe, RA, Price, JC, Benzinger, TL, Devous, MD, Jagust, WJ, Johnson, KA, Mathis, CA, Minhas, D, Pontecorvo, MJ, Rowe, CC, Skovronsky, DM & Mintun, MA 2015, 'The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET', Alzheimer's and Dementia, vol. 11, no. 1, pp. 1-15.e4. https://doi.org/10.1016/j.jalz.2014.07.003
Klunk, William E. ; Koeppe, Robert A. ; Price, Julie C. ; Benzinger, Tammie L. ; Devous, Michael D. ; Jagust, William J. ; Johnson, Keith A. ; Mathis, Chester A. ; Minhas, Davneet ; Pontecorvo, Michael J. ; Rowe, Christopher C. ; Skovronsky, Daniel M. ; Mintun, Mark A. / The Centiloid project : Standardizing quantitative amyloid plaque estimation by PET. In: Alzheimer's and Dementia. 2015 ; Vol. 11, No. 1. pp. 1-15.e4.
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