The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET

William E. Klunk; Robert A. Koeppe; Julie C. Price; Tammie L. Benzinger; Michael D. Devous; William J. Jagust; Keith A. Johnson; Chester A. Mathis; Davneet Minhas; Michael J. Pontecorvo; Christopher C. Rowe; Daniel M. Skovronsky; Mark A. Mintun

doi:10.1016/j.jalz.2014.07.003

The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET

William E. Klunk, Robert A. Koeppe, Julie C. Price, Tammie L. Benzinger, Michael D. Devous, William J. Jagust, Keith A. Johnson, Chester A. Mathis, Davneet Minhas, Michael J. Pontecorvo, Christopher C. Rowe, Daniel M. Skovronsky, Mark A. Mintun

Radiology

Research output: Contribution to journal › Article › peer-review

551 Scopus citations

Abstract

Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

Original language	English (US)
Pages (from-to)	1-15.e4
Journal	Alzheimer's and Dementia
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2014.07.003
State	Published - 2015

Keywords

Amyloid imaging
Centiloid scale
Pittsburgh compound B
Positron emission tomography
Standardize

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

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10.1016/j.jalz.2014.07.003

Cite this

Klunk, W. E., Koeppe, R. A., Price, J. C., Benzinger, T. L., Devous, M. D., Jagust, W. J., Johnson, K. A., Mathis, C. A., Minhas, D., Pontecorvo, M. J., Rowe, C. C., Skovronsky, D. M., & Mintun, M. A. (2015). The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET. Alzheimer's and Dementia, 11(1), 1-15.e4. https://doi.org/10.1016/j.jalz.2014.07.003

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year = "2015",

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AU - Johnson, Keith A.

AU - Mathis, Chester A.

AU - Minhas, Davneet

AU - Pontecorvo, Michael J.

AU - Rowe, Christopher C.

AU - Skovronsky, Daniel M.

AU - Mintun, Mark A.

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N2 - Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

AB - Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

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The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET

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