The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling

Xin Cai, Yu Hsin Chiu, Zhijian J. Chen

Research output: Contribution to journalReview article

371 Scopus citations

Abstract

The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic acids represent amajor class of pathogen signatures that can trigger robust immune responses. The presence of DNA inthecytoplasm of mammalian cells is a danger signal that activates innate immune responses; however, how cytosolic DNA triggers these responses remained unclear until recently. In this review, we focus onthe mechanism of DNA sensing by the newly discovered cGAS-cGAMP-STING pathway and highlight recent progress in dissecting the invivo functions of this pathway in immune defense as well as autoimmunity.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalMolecular cell
Volume54
Issue number2
DOIs
StatePublished - Apr 24 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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