TY - JOUR
T1 - The characterization of dendronized poly(ethylene glycol)s and poly(ethylene glycol) multi-arm stars using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
AU - Myers, Brittany K.
AU - Zhang, Boyu
AU - Lapucha, Joanna E.
AU - Grayson, Scott M.
N1 - Funding Information:
The authors acknowledge the financial support of Department of Defense ( W81XWH-10-1-0377 ) and the National Science Foundation under the NSF CAREER program (DMR 0844662). The authors also acknowledge Aldrich Materials Science, an initiative of Sigma–Aldrich for providing some of the polymers for analysis.
PY - 2014/1/15
Y1 - 2014/1/15
N2 - The synthesis of branched poly(ethylene glycol) (PEG) derivatives, namely star PEG and dendronized PEG, can be challenging and their purity can be difficult to ascertain using traditional techniques, such as NMR and GPC. Herein, the detailed characterization of these branched PEGs using MALDI-ToF MS was investigated in order to confirm their structural purity. In this light, mass spectrometry offers a number of advantages for polymer characterization, including the ability to get detailed structural data, such as end group masses, from microgram-scale samples. In addition, the ability to rapidly acquire data from crude reaction aliquots makes MALDI-ToF MS ideal for monitoring end group transformations.
AB - The synthesis of branched poly(ethylene glycol) (PEG) derivatives, namely star PEG and dendronized PEG, can be challenging and their purity can be difficult to ascertain using traditional techniques, such as NMR and GPC. Herein, the detailed characterization of these branched PEGs using MALDI-ToF MS was investigated in order to confirm their structural purity. In this light, mass spectrometry offers a number of advantages for polymer characterization, including the ability to get detailed structural data, such as end group masses, from microgram-scale samples. In addition, the ability to rapidly acquire data from crude reaction aliquots makes MALDI-ToF MS ideal for monitoring end group transformations.
KW - Dendronized polymers
KW - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS)
KW - Poly(ethylene glycol)
KW - Polymer characterization
KW - Star polymers
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U2 - 10.1016/j.aca.2013.09.038
DO - 10.1016/j.aca.2013.09.038
M3 - Article
C2 - 24370103
AN - SCOPUS:84890864879
VL - 808
SP - 175
EP - 189
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
SN - 0003-2670
ER -