The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Shuanhu Gao; Qiaoling Wang; Gelin Wang; Brett Lomenick; Jie Liu; Chih Wei Fan; Lih Wen Deng; Jing Huang; Lawrence Lum; Chuo Chen

doi:10.1055/S-0031-1290460

The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Shuanhu Gao, Qiaoling Wang, Gelin Wang, Brett Lomenick, Jie Liu, Chih Wei Fan, Lih Wen Deng, Jing Huang, Lawrence Lum, Chuo Chen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

Original language	English (US)
Article number	ST-2012-A0436-A
Pages (from-to)	2298-2310
Number of pages	13
Journal	Synlett
Volume	23
Issue number	16
DOIs	https://doi.org/10.1055/S-0031-1290460
State	Published - 2012

Keywords

Hedgehog signaling
Natural products
Steroids
Total synthesis
Tubulin

ASJC Scopus subject areas

Organic Chemistry

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10.1055/S-0031-1290460

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abstract = "Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.",

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AU - Wang, Qiaoling

AU - Wang, Gelin

AU - Lomenick, Brett

AU - Liu, Jie

AU - Fan, Chih Wei

AU - Deng, Lih Wen

AU - Huang, Jing

AU - Lum, Lawrence

AU - Chen, Chuo

PY - 2012

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AB - Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

KW - Hedgehog signaling

KW - Natural products

KW - Steroids

KW - Total synthesis

KW - Tubulin

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The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Abstract

Keywords

ASJC Scopus subject areas

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