The circadian clock in skin: Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity

Maksim V. Plikus, Elyse N. Van Spyk, Kim Pham, Mikhail Geyfman, Vivek Kumar, Joseph S. Takahashi, Bogi Andersen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Historically, work on peripheral circadian clocks has been focused on organs and tissues that have prominent metabolic functions, such as the liver, fat, and muscle. In recent years, skin has emerged as a model for studying circadian clock regulation of cell proliferation, stem cell functions, tissue regeneration, aging, and carcinogenesis. Morphologically, skin is complex, containing multiple cell types and structures, and there is evidence for a functional circadian clock in most, if not all, of its cell types. Despite the complexity, skin stem cell populations are well defined, experimentally tractable, and exhibit prominent daily cell proliferation cycles. Hair follicle stem cells also participate in recurrent, long-lasting cycles of regeneration: the hair growth cycles. Among other advantages of skin is a broad repertoire of available genetic tools enabling the creation of cell type-specific circadian mutants. Also, due to the accessibility of skin, in vivo imaging techniques can be readily applied to study the circadian clock and its outputs in real time, even at the single-cell level. Skin provides the first line of defense against many environmental and stress factors that exhibit dramatic diurnal variations such as solar ultraviolet (UV) radiation and temperature. Studies have already linked the circadian clock to the control of UVB-induced DNA damage and skin cancers. Due to the important role that skin plays in the defense against microorganisms, it also represents a promising model system to further explore the role of the clock in the regulation of the body's immune functions. To that end, recent studies have already linked the circadian clock to psoriasis, one of the most common immune-mediated skin disorders. Skin also provides opportunities to interrogate the clock regulation of tissue metabolism in the context of stem cells and regeneration. Furthermore, many animal species feature prominent seasonal hair molt cycles, offering an attractive model for investigating the role of the clock in seasonal organismal behaviors.

Original languageEnglish (US)
Pages (from-to)163-182
Number of pages20
JournalJournal of Biological Rhythms
Volume30
Issue number3
DOIs
StatePublished - Jun 4 2015

Fingerprint

Circadian Clocks
Adult Stem Cells
Regeneration
Immunity
Skin
Neoplasms
Stem Cells
Hair
Cell Proliferation
Hair Follicle
Skin Neoplasms
Psoriasis
DNA Damage
Cell Cycle
Carcinogenesis
Fats
Radiation
Muscles
Temperature
Liver

Keywords

  • aging
  • autoimmune diseases
  • cancer
  • cell cycle
  • hair follicle
  • immunity
  • regeneration
  • skin
  • stem cells
  • UV exposure

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

The circadian clock in skin : Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity. / Plikus, Maksim V.; Van Spyk, Elyse N.; Pham, Kim; Geyfman, Mikhail; Kumar, Vivek; Takahashi, Joseph S.; Andersen, Bogi.

In: Journal of Biological Rhythms, Vol. 30, No. 3, 04.06.2015, p. 163-182.

Research output: Contribution to journalArticle

Plikus, Maksim V. ; Van Spyk, Elyse N. ; Pham, Kim ; Geyfman, Mikhail ; Kumar, Vivek ; Takahashi, Joseph S. ; Andersen, Bogi. / The circadian clock in skin : Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity. In: Journal of Biological Rhythms. 2015 ; Vol. 30, No. 3. pp. 163-182.
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