The circadian Clock mutation alters sleep homeostasis in the mouse

E. Naylor, B. M. Bergmann, K. Krauski, P. C. Zee, J. S. Takahashi, M. H. Vitaterna, F. W. Turek

Research output: Contribution to journalArticle

283 Citations (Scopus)

Abstract

The onset and duration of sleep are thought to be primarily under the control of a homeostatic mechanism affected by previous periods of wake and sleep and a circadian timing mechanism that partitions wake and sleep into different portions of the day and night. The mouse Clock mutation induces pronounced changes in overall circadian organization. We sought to determine whether this genetic disruption of circadian timing would affect sleep homeostasis. The Clock mutation affected a number of sleep parameters during entrainment to a 12 hr light/dark (LD 12:12) cycle, when animals were free-running in constant darkness (DD), and during recovery from 6 hr of sleep deprivation in LD 12:12. In particular, in LD 12:12, heterozygous and homozygous Clock mutants slept, respectively, ~1 and ~2 hr less than wild-type mice, and they had 25 and 51% smaller increases in rapid eye movement (REM) sleep during 24 hr recovery, respectively, than wild-type mice. The effects of the mutation on sleep are not readily attributable to differential entrainment to LD 12:12 because the baseline sleep differences between genotypes were also present when animals were free-running in DD. These results indicate that genetic alterations of the circadian clock system and/or its regulatory genes are likely to have widespread effects on a variety of sleep and wake parameters, including the homeostatic regulation of sleep.

Original languageEnglish (US)
Pages (from-to)8138-8143
Number of pages6
JournalJournal of Neuroscience
Volume20
Issue number21
StatePublished - Nov 1 2000

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Circadian Clocks
Sleep
Homeostasis
Mutation
Running
Sleep Deprivation
Darkness
REM Sleep
Regulator Genes
Genotype
Light

Keywords

  • Circadian
  • Clock mutation
  • Gene
  • NREM delta power
  • REM
  • Sleep
  • Sleep homeostasis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000). The circadian Clock mutation alters sleep homeostasis in the mouse. Journal of Neuroscience, 20(21), 8138-8143.

The circadian Clock mutation alters sleep homeostasis in the mouse. / Naylor, E.; Bergmann, B. M.; Krauski, K.; Zee, P. C.; Takahashi, J. S.; Vitaterna, M. H.; Turek, F. W.

In: Journal of Neuroscience, Vol. 20, No. 21, 01.11.2000, p. 8138-8143.

Research output: Contribution to journalArticle

Naylor, E, Bergmann, BM, Krauski, K, Zee, PC, Takahashi, JS, Vitaterna, MH & Turek, FW 2000, 'The circadian Clock mutation alters sleep homeostasis in the mouse', Journal of Neuroscience, vol. 20, no. 21, pp. 8138-8143.
Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH et al. The circadian Clock mutation alters sleep homeostasis in the mouse. Journal of Neuroscience. 2000 Nov 1;20(21):8138-8143.
Naylor, E. ; Bergmann, B. M. ; Krauski, K. ; Zee, P. C. ; Takahashi, J. S. ; Vitaterna, M. H. ; Turek, F. W. / The circadian Clock mutation alters sleep homeostasis in the mouse. In: Journal of Neuroscience. 2000 ; Vol. 20, No. 21. pp. 8138-8143.
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