The clearances of N-acetyl-D-glucosaminyl-bovine serum albumin (GlcNAc-BSA), L-fucosyl-bovine serum albumin (Fuc-BSA) and asialoorosomucoid (ASOR) were evaluated in alloxan-induced diabetic mice and compared to non-diabetic litter mates. The clearances of Fuc-BSA and ASOR were identical in both groups. However, the clearance of GlcNAc-BSA was considerably slower in the diabetic animals. When GlcNAc-BSA was injected into normal mice in the presence of a blood glucose of 25 to 50 mM, competition was observed. No competition was seen with Fuc-BSA or D-galactosyl-BSA (Gal-BSA) in the presence of 50 mM glucose. In, vitro binding studies with purified receptor for GlcNAc/mannose confirm that glucose competes for binding of GlcNAc-BSA to this receptor.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jul 30 1981|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology