The clearance rate of maternal plasma prehormones of placental estrogen formation.

N. F. Gant, R. J. Worley, P. C. MacDonald

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A method has been established for the determination of the placental clearance of maternal plasma prehormones by placental estrogen formation during human pregnancy. Utilizing this concept, the placental clearance is calculated as the product of the metabolic clearance rate from maternal plasma of the prehormone and its fractional conversion to estrogen by the placenta. This value equals the volume of maternal plasma cleared of that prehormone by the irreversible formation of its estrogenic product hormone per unit of time. The placental clearance rate technique can be performed by intravenous infusion of isotope-labeled prehormone and product, and the metabolic clearance rate as well as the transfer constant can be measured by techniques employing plasma values or by a combination of plasma and urinary methods. Utilizing this type of study, the placental clearance of plasma prehormones has been observed to be increased initially in women destined to develop pregnancy-induced hypertension but declines prior to the onset of hypertension and continues to decline until delivery is effected. Moreover, the administration of diuretics and/or the institution oental clearance of plasma prehormones from the maternal compartment in normal gravidas, in those destined to develop pregnancy-induced hypertension, and in gravidas who are hypertensive from any cause.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalPerspectives in nephrology and hypertension
Volume5
StatePublished - 1976

Fingerprint

Estrogens
Mothers
Metabolic Clearance Rate
Pregnancy Induced Hypertension
Plasma Volume
Diuretics
Intravenous Infusions
Isotopes
Placenta
Hormones
Hypertension
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The clearance rate of maternal plasma prehormones of placental estrogen formation. / Gant, N. F.; Worley, R. J.; MacDonald, P. C.

In: Perspectives in nephrology and hypertension, Vol. 5, 1976, p. 309-314.

Research output: Contribution to journalArticle

@article{04bb8de080454d9aac7672b7e408ae1b,
title = "The clearance rate of maternal plasma prehormones of placental estrogen formation.",
abstract = "A method has been established for the determination of the placental clearance of maternal plasma prehormones by placental estrogen formation during human pregnancy. Utilizing this concept, the placental clearance is calculated as the product of the metabolic clearance rate from maternal plasma of the prehormone and its fractional conversion to estrogen by the placenta. This value equals the volume of maternal plasma cleared of that prehormone by the irreversible formation of its estrogenic product hormone per unit of time. The placental clearance rate technique can be performed by intravenous infusion of isotope-labeled prehormone and product, and the metabolic clearance rate as well as the transfer constant can be measured by techniques employing plasma values or by a combination of plasma and urinary methods. Utilizing this type of study, the placental clearance of plasma prehormones has been observed to be increased initially in women destined to develop pregnancy-induced hypertension but declines prior to the onset of hypertension and continues to decline until delivery is effected. Moreover, the administration of diuretics and/or the institution oental clearance of plasma prehormones from the maternal compartment in normal gravidas, in those destined to develop pregnancy-induced hypertension, and in gravidas who are hypertensive from any cause.",
author = "Gant, {N. F.} and Worley, {R. J.} and MacDonald, {P. C.}",
year = "1976",
language = "English (US)",
volume = "5",
pages = "309--314",
journal = "Perspectives in nephrology and hypertension",
issn = "0092-2900",

}

TY - JOUR

T1 - The clearance rate of maternal plasma prehormones of placental estrogen formation.

AU - Gant, N. F.

AU - Worley, R. J.

AU - MacDonald, P. C.

PY - 1976

Y1 - 1976

N2 - A method has been established for the determination of the placental clearance of maternal plasma prehormones by placental estrogen formation during human pregnancy. Utilizing this concept, the placental clearance is calculated as the product of the metabolic clearance rate from maternal plasma of the prehormone and its fractional conversion to estrogen by the placenta. This value equals the volume of maternal plasma cleared of that prehormone by the irreversible formation of its estrogenic product hormone per unit of time. The placental clearance rate technique can be performed by intravenous infusion of isotope-labeled prehormone and product, and the metabolic clearance rate as well as the transfer constant can be measured by techniques employing plasma values or by a combination of plasma and urinary methods. Utilizing this type of study, the placental clearance of plasma prehormones has been observed to be increased initially in women destined to develop pregnancy-induced hypertension but declines prior to the onset of hypertension and continues to decline until delivery is effected. Moreover, the administration of diuretics and/or the institution oental clearance of plasma prehormones from the maternal compartment in normal gravidas, in those destined to develop pregnancy-induced hypertension, and in gravidas who are hypertensive from any cause.

AB - A method has been established for the determination of the placental clearance of maternal plasma prehormones by placental estrogen formation during human pregnancy. Utilizing this concept, the placental clearance is calculated as the product of the metabolic clearance rate from maternal plasma of the prehormone and its fractional conversion to estrogen by the placenta. This value equals the volume of maternal plasma cleared of that prehormone by the irreversible formation of its estrogenic product hormone per unit of time. The placental clearance rate technique can be performed by intravenous infusion of isotope-labeled prehormone and product, and the metabolic clearance rate as well as the transfer constant can be measured by techniques employing plasma values or by a combination of plasma and urinary methods. Utilizing this type of study, the placental clearance of plasma prehormones has been observed to be increased initially in women destined to develop pregnancy-induced hypertension but declines prior to the onset of hypertension and continues to decline until delivery is effected. Moreover, the administration of diuretics and/or the institution oental clearance of plasma prehormones from the maternal compartment in normal gravidas, in those destined to develop pregnancy-induced hypertension, and in gravidas who are hypertensive from any cause.

UR - http://www.scopus.com/inward/record.url?scp=0017245536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017245536&partnerID=8YFLogxK

M3 - Article

C2 - 137386

AN - SCOPUS:0017245536

VL - 5

SP - 309

EP - 314

JO - Perspectives in nephrology and hypertension

JF - Perspectives in nephrology and hypertension

SN - 0092-2900

ER -