The clinical relevance of the clopidogrel-proton pump inhibitor interaction

Atif Mohammad; Emmanouil S. Brilakis; Rick A. Weideman; Bertis B. Little; Subhash Banerjee

doi:10.1007/s12265-011-9334-7

The clinical relevance of the clopidogrel-proton pump inhibitor interaction

Atif Mohammad, Emmanouil S. Brilakis, Rick A. Weideman, Bertis B. Little, Subhash Banerjee

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel-proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.

Original language	English (US)
Pages (from-to)	547-552
Number of pages	6
Journal	Journal of cardiovascular translational research
Volume	5
Issue number	4
DOIs	https://doi.org/10.1007/s12265-011-9334-7
State	Published - Aug 2012

Keywords

Clopidogrel
Drug interaction
Percutaneous coronary intervention
Proton pump inhibitor

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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10.1007/s12265-011-9334-7

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AU - Banerjee, Subhash

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AB - Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel-proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.

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The clinical relevance of the clopidogrel-proton pump inhibitor interaction

Abstract

Keywords

ASJC Scopus subject areas

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