Abstract
Chronic metabolic acidosis is a process whereby an excess nonvolatile acid load is chronically placed on the body due to excess acid generation or diminished acid removal by normal homeostatic mechanisms. Two common, often- overlooked clinical conditions associated with chronic metabolic acidosis are aging and excessive meat ingestion. Because the body's homeostatic response to these pathologic processes is very efficient, the serum HCO3 - and blood pH are frequently maintained within the 'normal' range. Nevertheless, these homeostatic responses engender pathologic consequences, such as nephrolithiasis, bone demineralization, muscle protein breakdown, and renal growth. Based on this, the concept of eubicarbonatemic metabolic acidosis is introduced. Even in patients with a normal serum HCO3 - and blood pH, it is important to treat the acid load and prevent pathologic homeostatic responses. These homeostatic responses, as well as the mechanisms responsible for their initiation, are reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-302 |
| Number of pages | 12 |
| Journal | American Journal of Kidney Diseases |
| Volume | 29 |
| Issue number | 2 |
| State | Published - Feb 1997 |
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Keywords
- bone
- c-src
- Citrate
- muscle catabolism
- nephrolithiasis
ASJC Scopus subject areas
- Nephrology
Cite this
The clinical spectrum of chronic metabolic acidosis : Homeostatic mechanisms produce significant morbidity. / Alpern, Robert J.; Sakhaee, Khashayar.
In: American Journal of Kidney Diseases, Vol. 29, No. 2, 02.1997, p. 291-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The clinical spectrum of chronic metabolic acidosis
T2 - Homeostatic mechanisms produce significant morbidity
AU - Alpern, Robert J.
AU - Sakhaee, Khashayar
PY - 1997/2
Y1 - 1997/2
N2 - Chronic metabolic acidosis is a process whereby an excess nonvolatile acid load is chronically placed on the body due to excess acid generation or diminished acid removal by normal homeostatic mechanisms. Two common, often- overlooked clinical conditions associated with chronic metabolic acidosis are aging and excessive meat ingestion. Because the body's homeostatic response to these pathologic processes is very efficient, the serum HCO3 - and blood pH are frequently maintained within the 'normal' range. Nevertheless, these homeostatic responses engender pathologic consequences, such as nephrolithiasis, bone demineralization, muscle protein breakdown, and renal growth. Based on this, the concept of eubicarbonatemic metabolic acidosis is introduced. Even in patients with a normal serum HCO3 - and blood pH, it is important to treat the acid load and prevent pathologic homeostatic responses. These homeostatic responses, as well as the mechanisms responsible for their initiation, are reviewed.
AB - Chronic metabolic acidosis is a process whereby an excess nonvolatile acid load is chronically placed on the body due to excess acid generation or diminished acid removal by normal homeostatic mechanisms. Two common, often- overlooked clinical conditions associated with chronic metabolic acidosis are aging and excessive meat ingestion. Because the body's homeostatic response to these pathologic processes is very efficient, the serum HCO3 - and blood pH are frequently maintained within the 'normal' range. Nevertheless, these homeostatic responses engender pathologic consequences, such as nephrolithiasis, bone demineralization, muscle protein breakdown, and renal growth. Based on this, the concept of eubicarbonatemic metabolic acidosis is introduced. Even in patients with a normal serum HCO3 - and blood pH, it is important to treat the acid load and prevent pathologic homeostatic responses. These homeostatic responses, as well as the mechanisms responsible for their initiation, are reviewed.
KW - bone
KW - c-src
KW - Citrate
KW - muscle catabolism
KW - nephrolithiasis
UR - http://www.scopus.com/inward/record.url?scp=0030891508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030891508&partnerID=8YFLogxK
M3 - Article
C2 - 9016905
AN - SCOPUS:0030891508
VL - 29
SP - 291
EP - 302
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 2
ER -