The collaborative work of droplet assembly

Xiao Chen, Joel M. Goodman

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Keywords

  • FIT2
  • Lipodystrophy
  • Perilipin
  • Pet10
  • Seipin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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