Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
|Original language||English (US)|
|Journal||Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids|
|State||Accepted/In press - 2017|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology