The collaborative work of droplet assembly

Xiao Chen, Joel M. Goodman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

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Proteins
Lipid Droplets
Perilipin-1

Keywords

  • FIT2
  • Lipodystrophy
  • Perilipin
  • Pet10
  • Seipin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

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title = "The collaborative work of droplet assembly",
abstract = "Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.",
keywords = "FIT2, Lipodystrophy, Perilipin, Pet10, Seipin",
author = "Xiao Chen and Goodman, {Joel M.}",
year = "2017",
doi = "10.1016/j.bbalip.2017.07.003",
language = "English (US)",
journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",
issn = "1388-1981",
publisher = "Elsevier",

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AU - Chen, Xiao

AU - Goodman, Joel M.

PY - 2017

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AB - Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

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KW - Lipodystrophy

KW - Perilipin

KW - Pet10

KW - Seipin

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U2 - 10.1016/j.bbalip.2017.07.003

DO - 10.1016/j.bbalip.2017.07.003

M3 - Article

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

SN - 1388-1981

ER -