The collagen recognition sequence for fibroblasts depends on collagen topography

Frederick Grinnell, Shigenori Nakagawa, Chin Han Ho

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We found that the peptide GlyArgGlyGluSerPro (GRGESP) inhibited spreading of human fibroblasts inside collagen gels and markedly decreased gel contraction, but this peptide had no effect on cell spreading on collagen-coated surfaces. On the other hand, the peptide GlyArgGlyAspSerPro (GRGDSP), which inhibited cell spreading on collagen-coated surfaces, did not inhibit cell spreading within collagen gels and was a less effective inhibitor of collagen gel contraction than GRGESP. Based on these findings, we conclude that human fibroblasts can interact with different collagen cell recognition sequences depending upon topographical organization of the collagen.

Original languageEnglish (US)
Pages (from-to)668-672
Number of pages5
JournalExperimental Cell Research
Volume182
Issue number2
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Cell Biology

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