The collagen recognition sequence for fibroblasts depends on collagen topography

Frederick Grinnell, Shigenori Nakagawa, Chin Han Ho

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We found that the peptide GlyArgGlyGluSerPro (GRGESP) inhibited spreading of human fibroblasts inside collagen gels and markedly decreased gel contraction, but this peptide had no effect on cell spreading on collagen-coated surfaces. On the other hand, the peptide GlyArgGlyAspSerPro (GRGDSP), which inhibited cell spreading on collagen-coated surfaces, did not inhibit cell spreading within collagen gels and was a less effective inhibitor of collagen gel contraction than GRGESP. Based on these findings, we conclude that human fibroblasts can interact with different collagen cell recognition sequences depending upon topographical organization of the collagen.

Original languageEnglish (US)
Pages (from-to)668-672
Number of pages5
JournalExperimental Cell Research
Volume182
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Collagen
Fibroblasts
glycyl-arginyl-glycyl-glutamyl-seryl-proline
Gels
glycyl-arginyl-glycyl-aspartyl-seryl-proline
Peptides

ASJC Scopus subject areas

  • Cell Biology

Cite this

The collagen recognition sequence for fibroblasts depends on collagen topography. / Grinnell, Frederick; Nakagawa, Shigenori; Ho, Chin Han.

In: Experimental Cell Research, Vol. 182, No. 2, 1989, p. 668-672.

Research output: Contribution to journalArticle

Grinnell, Frederick ; Nakagawa, Shigenori ; Ho, Chin Han. / The collagen recognition sequence for fibroblasts depends on collagen topography. In: Experimental Cell Research. 1989 ; Vol. 182, No. 2. pp. 668-672.
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