The Columnar Epithelial Cell of the Small Intestine: Digestion and Transport

Jerry D. Gardner, Michael S. Brown, Leonard Laster

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Hexose Absorption After direct evidence was obtained for the role of the intestinal epithelial cell in sugar absorption,94 it was shown that mucosal sheets, intact rings and isolated villi from hamster small intestine can accumulate such an amount of sugar that tissue concentration exceeds medium concentration95 and sugar uptake is energy dependent and exhibits Michaelis–Menten kinetics,80 mutual competitive inhibition and phlorizin inhibition.55,95 96 97 98 99 Sugar entry and accumulation were attributed to a carrier mechanism in the brush-border membrane, with entry reflecting unidirectional movement into the tissue and accumulation reflecting the tissue concentration at which sugar entry equals exit. For absorption of sugars.

Original languageEnglish (US)
Pages (from-to)1264-1271
Number of pages8
JournalNew England Journal of Medicine
Volume283
Issue number23
DOIs
StatePublished - Dec 3 1970
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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