The complex interplay between mitochondrial dynamics and cardiac metabolism

Valentina Parra, Hugo Verdejo, Andrea Del Campo, Christian Pennanen, Jovan Kuzmicic, Myriam Iglewski, Joseph A Hill, Beverly A Rothermel, Sergio Lavandero

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalJournal of Bioenergetics and Biomembranes
Volume43
Issue number1
DOIs
StatePublished - Feb 1 2011

Keywords

  • Fission
  • Fusion
  • Heart
  • Metabolism
  • Mitochondria
  • Mitochondrial dynamics

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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