The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez, Hongtao Yu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.

Original languageEnglish (US)
Article numbere969658
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 3 2015

Keywords

  • apoptosis
  • cell death
  • mitochondrial fusion
  • mitosis
  • taxol

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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