The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez, Hongtao Yu

Research output: Contribution to journalArticle

Abstract

The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.

Original languageEnglish (US)
Article numbere969658
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 3 2015

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Paclitaxel
Mitosis
Microtubules
Pharmaceutical Preparations
Neoplasms

Keywords

  • apoptosis
  • cell death
  • mitochondrial fusion
  • mitosis
  • taxol

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

Cite this

The complexity of life and death decisions in mitosis. / Diaz-Martinez, Laura A.; Yu, Hongtao.

In: Molecular and Cellular Oncology, Vol. 2, No. 2, e969658, 03.04.2015.

Research output: Contribution to journalArticle

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