The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez; Hongtao Yu

doi:10.4161/23723548.2014.969658

The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez, Hongtao Yu

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.

Original language	English (US)
Article number	e969658
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723548.2014.969658
State	Published - Apr 3 2015

Keywords

apoptosis
cell death
mitochondrial fusion
mitosis
taxol

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723548.2014.969658

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title = "The complexity of life and death decisions in mitosis",

abstract = "The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.",

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The complexity of life and death decisions in mitosis

Abstract

Keywords

ASJC Scopus subject areas

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