The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions

Michael K. Rosen, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Analyses of the complexation of cyclosporin A (CsA) by cyclophilin and the unusual properties of MeBm2t1-CsA lead us to propose a conformational change upon binding of the cyclophilin-CsA complex to the protein phosphatase, calcineurin.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number7
DOIs
StatePublished - 1992

Fingerprint

Cyclophilins
Calcineurin
Cyclosporine
Conformations
Ligands
Phosphoprotein Phosphatases
Complexation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin : an analysis of receptor-ligand-receptor interactions. / Rosen, Michael K.; Belshaw, Peter J.; Alberg, David G.; Schreiber, Stuart L.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 2, No. 7, 1992, p. 747-753.

Research output: Contribution to journalArticle

@article{b01974c66fad42c1ab99ba30c86c6180,
title = "The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions",
abstract = "Analyses of the complexation of cyclosporin A (CsA) by cyclophilin and the unusual properties of MeBm2t1-CsA lead us to propose a conformational change upon binding of the cyclophilin-CsA complex to the protein phosphatase, calcineurin.",
author = "Rosen, {Michael K.} and Belshaw, {Peter J.} and Alberg, {David G.} and Schreiber, {Stuart L.}",
year = "1992",
doi = "10.1016/S0960-894X(00)80405-9",
language = "English (US)",
volume = "2",
pages = "747--753",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin

T2 - an analysis of receptor-ligand-receptor interactions

AU - Rosen, Michael K.

AU - Belshaw, Peter J.

AU - Alberg, David G.

AU - Schreiber, Stuart L.

PY - 1992

Y1 - 1992

N2 - Analyses of the complexation of cyclosporin A (CsA) by cyclophilin and the unusual properties of MeBm2t1-CsA lead us to propose a conformational change upon binding of the cyclophilin-CsA complex to the protein phosphatase, calcineurin.

AB - Analyses of the complexation of cyclosporin A (CsA) by cyclophilin and the unusual properties of MeBm2t1-CsA lead us to propose a conformational change upon binding of the cyclophilin-CsA complex to the protein phosphatase, calcineurin.

UR - http://www.scopus.com/inward/record.url?scp=0026667668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026667668&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)80405-9

DO - 10.1016/S0960-894X(00)80405-9

M3 - Article

AN - SCOPUS:0026667668

VL - 2

SP - 747

EP - 753

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 7

ER -