The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions

Michael K. Rosen, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Analyses of the complexation of cyclosporin A (CsA) by cyclophilin and the unusual properties of MeBm2t1-CsA lead us to propose a conformational change upon binding of the cyclophilin-CsA complex to the protein phosphatase, calcineurin.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number7
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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