The contribution of αβ-tubulin curvature to microtubule dynamics

Gary J. Brouhard, Luke M. Rice

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubuleassociated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymerized αβ-tubulin. The ability of αβ-tubulin to adopt distinct conformations contributes to the intrinsic polymerization dynamics of microtubules. αβ-Tubulin conformation is a fundamental property that MAPs monitor and control to build proper microtubule networks.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalJournal of Cell Biology
Volume207
Issue number3
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Cell Biology

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