The convergent synthesis of novel cytotoxic certonardosterol D2 from diosgenin

Biao Jiang, He ping Shi, Wei sheng Tian, Wei shan Zhou

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Certonardosterol D2, a polyhydroxysterol isolated from starfish Certonardoa semiregularis with exceptionally potent antitumor activity, was stereoselectively synthesized from natural rich diosgenin via the protocol of Julia olefination and Evans aldol reaction.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalTetrahedron
Volume64
Issue number3
DOIs
Publication statusPublished - Jan 14 2008

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Keywords

  • Certonardosterol
  • Evans aldol reaction
  • Julia olefination
  • Polyhydroxysterol

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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