The convergent synthesis of novel cytotoxic certonardosterol D2 from diosgenin

Biao Jiang, He ping Shi, Wei sheng Tian, Wei shan Zhou

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Certonardosterol D2, a polyhydroxysterol isolated from starfish Certonardoa semiregularis with exceptionally potent antitumor activity, was stereoselectively synthesized from natural rich diosgenin via the protocol of Julia olefination and Evans aldol reaction.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalTetrahedron
Volume64
Issue number3
DOIs
StatePublished - Jan 14 2008

Keywords

  • Certonardosterol
  • Evans aldol reaction
  • Julia olefination
  • Polyhydroxysterol

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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