The correspondence between the labeling patterns of antibody RT97, neurofilaments, microtubule associated protein 1B and tau varies with cell types and development stages of chicken retina

Hoon Shin Dong, Kun Sei Lee, Eunju Lee, Sun Cho Sa, Jaehyup Kim, Wan Kim Jong, Sun Kwon Bum, Won Lee Hye, Jae Lee Wang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The correspondence between the labeling patterns of antibody RT97, neurofilaments (NF-M and NF-H), microtubule associated protein 1B (MAP1B) and tau, were studied in the developing chicken. At embryonic day 3 (E3), intense RT97 immunoreactivity (IR) was found to be localized in cells in the region adjacent to the intraretinal space, which separates the inner and outer layers of the optic cup, and this was sustained at E8. However, this pattern changed dramatically at E12, as the intensities of RT97 IR increased in the inner retinal layer, while the outermost layers showed only weak IR. The adult stage retina showed RT97 IR within the nerve fibers of the ganglion cells, the processes of the amacrine cells and the photoreceptors. Additional immunostainings for NF-M, -H, MAP1B and tau showed that the observed changes in RT97 IRs were due to the different expressions of these proteins at different development stages.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalNeuroscience letters
Volume342
Issue number3
DOIs
StatePublished - May 22 2003
Externally publishedYes

Keywords

  • Chicken
  • Development
  • Immunocytochemistry
  • RT97
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)

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