The Critical Role of Androgens in Prostate Development

Jean D. Wilson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Androgens are involved in every aspect of prostate development, growth, and function from early in male embryogenesis to prostatic hyperplasia in aging men and dogs. Likewise, androgen deprivation at any phase of life causes a decrease in prostate cell number and DNA content. The process by which the circulating androgen testosterone is converted to dihydrotestosterone in the tissue and dihydrotestosterone in turn gains access to the nucleus where it regulates gene expression, largely via interaction with a receptor protein, is understood, but the downstream control mechanisms by which hormonal signals are translated into differentiation, growth, and function are being unraveled.

Original languageEnglish (US)
Pages (from-to)577-590
Number of pages14
JournalEndocrinology and Metabolism Clinics of North America
Volume40
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Androgens
Prostate
Dihydrotestosterone
Prostatic Hyperplasia
Growth and Development
Embryonic Development
Testosterone
Cell Count
Dogs
Gene Expression
DNA
Growth
Proteins

Keywords

  • Androgen
  • Androgen receptor
  • Dihydrotestosterone
  • Leydig cell
  • Testosterone
  • Urogenital sinus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The Critical Role of Androgens in Prostate Development. / Wilson, Jean D.

In: Endocrinology and Metabolism Clinics of North America, Vol. 40, No. 3, 09.2011, p. 577-590.

Research output: Contribution to journalArticle

@article{57b88b5265cf476a8385688c142bafa1,
title = "The Critical Role of Androgens in Prostate Development",
abstract = "Androgens are involved in every aspect of prostate development, growth, and function from early in male embryogenesis to prostatic hyperplasia in aging men and dogs. Likewise, androgen deprivation at any phase of life causes a decrease in prostate cell number and DNA content. The process by which the circulating androgen testosterone is converted to dihydrotestosterone in the tissue and dihydrotestosterone in turn gains access to the nucleus where it regulates gene expression, largely via interaction with a receptor protein, is understood, but the downstream control mechanisms by which hormonal signals are translated into differentiation, growth, and function are being unraveled.",
keywords = "Androgen, Androgen receptor, Dihydrotestosterone, Leydig cell, Testosterone, Urogenital sinus",
author = "Wilson, {Jean D.}",
year = "2011",
month = "9",
doi = "10.1016/j.ecl.2011.05.003",
language = "English (US)",
volume = "40",
pages = "577--590",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - The Critical Role of Androgens in Prostate Development

AU - Wilson, Jean D.

PY - 2011/9

Y1 - 2011/9

N2 - Androgens are involved in every aspect of prostate development, growth, and function from early in male embryogenesis to prostatic hyperplasia in aging men and dogs. Likewise, androgen deprivation at any phase of life causes a decrease in prostate cell number and DNA content. The process by which the circulating androgen testosterone is converted to dihydrotestosterone in the tissue and dihydrotestosterone in turn gains access to the nucleus where it regulates gene expression, largely via interaction with a receptor protein, is understood, but the downstream control mechanisms by which hormonal signals are translated into differentiation, growth, and function are being unraveled.

AB - Androgens are involved in every aspect of prostate development, growth, and function from early in male embryogenesis to prostatic hyperplasia in aging men and dogs. Likewise, androgen deprivation at any phase of life causes a decrease in prostate cell number and DNA content. The process by which the circulating androgen testosterone is converted to dihydrotestosterone in the tissue and dihydrotestosterone in turn gains access to the nucleus where it regulates gene expression, largely via interaction with a receptor protein, is understood, but the downstream control mechanisms by which hormonal signals are translated into differentiation, growth, and function are being unraveled.

KW - Androgen

KW - Androgen receptor

KW - Dihydrotestosterone

KW - Leydig cell

KW - Testosterone

KW - Urogenital sinus

UR - http://www.scopus.com/inward/record.url?scp=80052229450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052229450&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2011.05.003

DO - 10.1016/j.ecl.2011.05.003

M3 - Article

C2 - 21889722

AN - SCOPUS:80052229450

VL - 40

SP - 577

EP - 590

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 3

ER -