Abstract
The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the rings together; a large loosely structured apical domain that forms the ends of the cylinder; and a small slender intermediate domain that connects the two, creating side windows. The three-dimensional structure places most of the mutation-ally defined functional sites on the channel walls and its outward imaginations, and at the ends of the cylinder.
Original language | English (US) |
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Pages (from-to) | 578-586 |
Number of pages | 9 |
Journal | Nature |
Volume | 371 |
Issue number | 6498 |
DOIs | |
State | Published - 1994 |
ASJC Scopus subject areas
- General