The current spectrum of gastric polyps: A 1-year national study of over 120,000 patients

Susanne W. Carmack, Robert M. Genta, Christopher M. Schuler, M. Hossein Saboorian

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES:To use a large pathology database (Caris Diagnostics) to analyze the frequency and associations of gastric polyps in a nationwide US population.METHODS:A total of 121,564 esophagogastroduodenoscopy (EGD) procedures from private practices in 36 states in the Caris Diagnostics database from 1 April 2007 to 31 March 2008 were searched for the endoscopic designations of polyp, nodule, and mass, and for the pathological diagnoses that commonly present as gastric polyps. Pertinent demographic data, clinical indications for EGD, and information regarding Helicobacter pylori infection, reactive gastropathy, chronic inactive gastritis, and intestinal metaplasia were also obtained.RESULTS:A total of 78,909 of the 121,564 patients who underwent EGD had gastric biopsies. The prevalence of gastric polyps in the EGD population was 6.35; 77 were fundic gland polyps, 17 hyperplastic polypspolypoid foveolar hyperplasia, 0.69 adenomas, and 0.1 inflammatory fibroid polyps. Malignant neoplasms were slightly >2. None of the benign gastric polyps had a significant positive association with concurrent H. pylori infection; intestinal metaplasia was detected in the background of 52.2 of carcinoids, 29.6 of adenomas, 20.1 of xanthomas, and 13 of adenocarcinomas and hyperplastic polyps. Adenomas were rarely associated with synchronous adenocarcinomas.CONCLUSIONS:The relative prevalence of fundic gland polyps in this population was much higher than that reported earlier, most likely because of the widespread use of proton pump inhibitors. H. pylori- and atrophy-associated polyps, including adenomas, were less common than in earlier series.

Original languageEnglish (US)
Pages (from-to)1524-1532
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume104
Issue number6
DOIs
StatePublished - Jun 2009

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Polyps
Stomach
Digestive System Endoscopy
Adenoma
Helicobacter pylori
Metaplasia
Helicobacter Infections
Adenocarcinoma
Databases
Population
Xanthomatosis
Proton Pump Inhibitors
Private Practice
Carcinoid Tumor
Leiomyoma
Gastritis
Atrophy
Hyperplasia
Demography
Pathology

ASJC Scopus subject areas

  • Gastroenterology

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The current spectrum of gastric polyps : A 1-year national study of over 120,000 patients. / Carmack, Susanne W.; Genta, Robert M.; Schuler, Christopher M.; Saboorian, M. Hossein.

In: American Journal of Gastroenterology, Vol. 104, No. 6, 06.2009, p. 1524-1532.

Research output: Contribution to journalArticle

Carmack, Susanne W. ; Genta, Robert M. ; Schuler, Christopher M. ; Saboorian, M. Hossein. / The current spectrum of gastric polyps : A 1-year national study of over 120,000 patients. In: American Journal of Gastroenterology. 2009 ; Vol. 104, No. 6. pp. 1524-1532.
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