The CYP P450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation

Jorge H. Capdevila, J R Falck

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

The studies of the cytochrome P450 (P450) arachidonic acid (AA) monooxygenase, now established as a major pathway for the bioactivation of AA, have uncovered new and important functional roles for this enzyme system in cell and organ physiology, and in the metabolism of endogenous substrate. Past and present advances in P450 biochemistry and molecular biology are beginning to provide a description of the P450 isoform specificity of AA bioactivation, and the mechanisms of action and physiological relevance of the P450 metabolites. Associations between genetically controlled alterations in P450 function, expression, or regulation and functionally meaningful phenotypes point to the critical roles played by the AA monooxygenase in the control of systemic blood pressure and the pathophysiology of hypertension.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume285
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Pressure regulation
Cell signaling
Blood pressure
Mixed Function Oxygenases
Arachidonic Acid
Blood Pressure
Cell Physiological Phenomena
Biochemistry
Molecular biology
Physiology
Metabolites
Metabolism
Cytochrome P-450 Enzyme System
Molecular Biology
Protein Isoforms
Hypertension
Phenotype
Substrates
Enzymes

Keywords

  • Arachidonic acid monooxygenase
  • EETs
  • Fatty acid hydroxylases
  • HETEs
  • Hypertension
  • P450 ω-hydroxylases
  • P450 epoxygenases

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The CYP P450 arachidonic acid monooxygenases : From cell signaling to blood pressure regulation. / Capdevila, Jorge H.; Falck, J R.

In: Biochemical and Biophysical Research Communications, Vol. 285, No. 3, 2001, p. 571-576.

Research output: Contribution to journalArticle

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