The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt

Jorge H. Capdevila, Nataliya Pidkovka, Shaojun Mei, Yan Gong, J R Falck, John D. Imig, Raymond C. Harris, Wenhui Wang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Epoxyeicosatrienoic acids (EETs) regulate sodium excretion in the distal nephron. Results: Lack of a Cyp2c44 epoxygenase blunts the ERK1/2-mediated inhibition of ENaC and causes salt-sensitive hypertension. Conclusion: Cyp2c44 is the epoxygenase responsible for the synthesis of natriuretic EETs during increased salt intake. Significance: Roles for the human CYP2C8 and CYP2C9 epoxygenases as antihypertensive therapeutic targets are proposed.

Original languageEnglish (US)
Pages (from-to)4377-4386
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

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Epithelial Sodium Channels
Blood pressure
Salts
Blood Pressure
Nephrons
Antihypertensive Agents
Sodium
Hypertension
Acids
Therapeutics
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP2C9

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. / Capdevila, Jorge H.; Pidkovka, Nataliya; Mei, Shaojun; Gong, Yan; Falck, J R; Imig, John D.; Harris, Raymond C.; Wang, Wenhui.

In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 4377-4386.

Research output: Contribution to journalArticle

Capdevila, Jorge H. ; Pidkovka, Nataliya ; Mei, Shaojun ; Gong, Yan ; Falck, J R ; Imig, John D. ; Harris, Raymond C. ; Wang, Wenhui. / The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 7. pp. 4377-4386.
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