The cytotoxic saponin from heat-processed Achyranthes fauriei roots

Hye Hyun Yoo; Sung Won Kwon; Jeong Hill Park

doi:10.1248/bpb.29.1053

The cytotoxic saponin from heat-processed Achyranthes fauriei roots

Hye Hyun Yoo, Sung Won Kwon, Jeong Hill Park

Physiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.

Original language	English (US)
Pages (from-to)	1053-1055
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	5
DOIs	https://doi.org/10.1248/bpb.29.1053
State	Published - May 2006

Keywords

Achyranthes fauriei
Amaranthaceae
Bioassay-linked HPLC-ELSD
Chikusetsusaponin IVa
Cytotoxic activity

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.29.1053

Cite this

@article{98d70319964f42e6a8b941f08ff6d04a,

title = "The cytotoxic saponin from heat-processed Achyranthes fauriei roots",

abstract = "An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.",

keywords = "Achyranthes fauriei, Amaranthaceae, Bioassay-linked HPLC-ELSD, Chikusetsusaponin IVa, Cytotoxic activity",

author = "Yoo, {Hye Hyun} and Kwon, {Sung Won} and Park, {Jeong Hill}",

year = "2006",

month = may,

doi = "10.1248/bpb.29.1053",

language = "English (US)",

volume = "29",

pages = "1053--1055",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "5",

}

TY - JOUR

T1 - The cytotoxic saponin from heat-processed Achyranthes fauriei roots

AU - Yoo, Hye Hyun

AU - Kwon, Sung Won

AU - Park, Jeong Hill

PY - 2006/5

Y1 - 2006/5

N2 - An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.

AB - An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.

KW - Achyranthes fauriei

KW - Amaranthaceae

KW - Bioassay-linked HPLC-ELSD

KW - Chikusetsusaponin IVa

KW - Cytotoxic activity

UR - http://www.scopus.com/inward/record.url?scp=33646447679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646447679&partnerID=8YFLogxK

U2 - 10.1248/bpb.29.1053

DO - 10.1248/bpb.29.1053

M3 - Article

C2 - 16651746

AN - SCOPUS:33646447679

SN - 0918-6158

VL - 29

SP - 1053

EP - 1055

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 5

ER -

The cytotoxic saponin from heat-processed Achyranthes fauriei roots

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this