The cytotoxic saponin from heat-processed Achyranthes fauriei roots

Hye Hyun Yoo, Sung Won Kwon, Jeong Hill Park

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.

Original languageEnglish (US)
Pages (from-to)1053-1055
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume29
Issue number5
DOIs
StatePublished - May 1 2006

Keywords

  • Achyranthes fauriei
  • Amaranthaceae
  • Bioassay-linked HPLC-ELSD
  • Chikusetsusaponin IVa
  • Cytotoxic activity

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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