TY - JOUR
T1 - The DABBEC Phenotyping System
T2 - Towards a mechanistic understanding of CP/CPPS
AU - Allsop, Stephen A.
AU - Erstad, Derek J.
AU - Brook, Karolina
AU - Bhai, Salman F.
AU - Cohen, Jeffrey M.
AU - Dimitrakoff, Jordan D.
PY - 2011/2
Y1 - 2011/2
N2 - There is an urgent need to elucidate the mechanistic basis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), as the current methods of symptom-based diagnosis and treatment have failed. Here, we propose a phenotyping system that bridges the gap between the symptom-based diagnosis and treatment of the present and the mechanistic approach of the future. Our phenotyping system uses the Chronic Prostatitis Collaborative Research Network (CPCRN)-recommended algorithm in combination with the NIH Chronic Prostatitis Symptom Index (NIH-CPSI) as a basis for diagnosis, while incorporating novel domains for quantitative assessment and stratification of CP/CPPS patients. We believe this novel system will serve to help advance our understanding of the roles of the patient's genome and proteome in the etiology of CP/CPPS. We predict that, as we begin to understand the mechanistic basis of CP/CPPS pathology and progression, we will develop specific treatments that will aim to cure the disease, rather than merely quell the symptoms.
AB - There is an urgent need to elucidate the mechanistic basis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), as the current methods of symptom-based diagnosis and treatment have failed. Here, we propose a phenotyping system that bridges the gap between the symptom-based diagnosis and treatment of the present and the mechanistic approach of the future. Our phenotyping system uses the Chronic Prostatitis Collaborative Research Network (CPCRN)-recommended algorithm in combination with the NIH Chronic Prostatitis Symptom Index (NIH-CPSI) as a basis for diagnosis, while incorporating novel domains for quantitative assessment and stratification of CP/CPPS patients. We believe this novel system will serve to help advance our understanding of the roles of the patient's genome and proteome in the etiology of CP/CPPS. We predict that, as we begin to understand the mechanistic basis of CP/CPPS pathology and progression, we will develop specific treatments that will aim to cure the disease, rather than merely quell the symptoms.
UR - http://www.scopus.com/inward/record.url?scp=79951511557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951511557&partnerID=8YFLogxK
U2 - 10.1038/nrurol.2010.227
DO - 10.1038/nrurol.2010.227
M3 - Review article
C2 - 21243018
AN - SCOPUS:79951511557
SN - 1759-4812
VL - 8
SP - 107
EP - 113
JO - Nature Reviews Urology
JF - Nature Reviews Urology
IS - 2
ER -