The dead phosphatases society: a review of the emerging roles of pseudophosphatases

Veronika Reiterer, Krzysztof Pawłowski, Guillaume Desrochers, Arnim Pause, Hayley J. Sharpe, Hesso Farhan

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Phosphatases are a diverse family of enzymes, comprising at least 10 distinct protein folds. Like most other enzyme families, many have sequence variations that predict an impairment or loss of catalytic activity classifying them as pseudophosphatases. Research on pseudoenzymes is an emerging area of interest, with new biological functions repurposed from catalytically active relatives. Here, we provide an overview of the pseudophosphatases identified to date in all major phosphatase families. We will highlight the degeneration of the various catalytic sequence motifs and discuss the challenges associated with the experimental determination of catalytic inactivity. We will also summarize the role of pseudophosphatases in various diseases and discuss the major challenges and future directions in this field.

Original languageEnglish (US)
Pages (from-to)4198-4220
Number of pages23
JournalFEBS Journal
Volume287
Issue number19
DOIs
StatePublished - Oct 1 2020
Externally publishedYes

Keywords

  • dephosphorylation
  • phosphatase
  • pseudoenzymes
  • pseudophosphatase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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