TY - JOUR
T1 - The delicate balance between fat and muscle
T2 - Adipokines in metabolic disease and musculoskeletal inflammation
AU - Nawrocki, Andrea R.
AU - Scherer, Philipp E.
N1 - Funding Information:
ARN was supported by a post-doctoral fellowship from the Swiss National Science Foundation. PES is supported by NIH grant R01-DK55758. We thank Dr. Dan Stein, Albert Einstein College of Medicine, for kindly providing the pictures of intra- and intermyocellular lipid accumulation that were used in the figures. Thanks to Maria Trujillo and Martin Fisher for critical reading of the manuscript.
PY - 2004/6
Y1 - 2004/6
N2 - Adipose tissue has evolved as a complex organ with functions far beyond the mere storage of energy. Chronic oversupply of calories, common to Western-style diets, frequently goes hand-in-hand with an altered secretion pattern of adipokines and elevated plasma free fatty acid levels, known to modulate insulin sensitivity in skeletal muscle. Intramyocellular accumulation of lipids directly attenuates insulin signaling within myocytes via distinct kinases. Obesity is also accompanied by an enhanced basal inflammatory tone, originating from adipocytes and adipose tissue-associated macrophages. In addition, adipocytes accumulate within the skeletal muscle and exert direct paracrine effects on muscle insulin sensitivity.
AB - Adipose tissue has evolved as a complex organ with functions far beyond the mere storage of energy. Chronic oversupply of calories, common to Western-style diets, frequently goes hand-in-hand with an altered secretion pattern of adipokines and elevated plasma free fatty acid levels, known to modulate insulin sensitivity in skeletal muscle. Intramyocellular accumulation of lipids directly attenuates insulin signaling within myocytes via distinct kinases. Obesity is also accompanied by an enhanced basal inflammatory tone, originating from adipocytes and adipose tissue-associated macrophages. In addition, adipocytes accumulate within the skeletal muscle and exert direct paracrine effects on muscle insulin sensitivity.
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U2 - 10.1016/j.coph.2004.03.003
DO - 10.1016/j.coph.2004.03.003
M3 - Review article
C2 - 15140421
AN - SCOPUS:2342648825
SN - 1471-4892
VL - 4
SP - 281
EP - 289
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 3
ER -