The desirability of treatment with multiple fields in charged heavy particle therapy

D. A. Pistenma, G. C. Li, M. A. Bagshaw

Research output: Contribution to journalArticle

Abstract

Many parallels exist in treatment planning for charged heavy particles, X-rays and neutrons. The charged particles, however, offer improved dose distributions because of their finite range. Parallel opposed, as compared to single port, irradiation with pions, helium ions and heavier ions is advantageous because of improved tumour-to-entrance-region dose ratios and more uniform distributions of the high LET radiation events throughout the tumour volumes. The clinical significance of the variations of RBE and OER with pion star fraction (or density of high LET events with the other charged heavy particles) remains to be elucidated for fractionation schemes which might be used for patient treatment. This will also be important for the evaluation of mixed heavy ion and X-ray irradiation if it is necessitated by the high RBE in the entrance region with neon and other heavy ions, or is shown to be an effective way to use heavy ions. The advantages of irradiation with the cylindrical geometry of the Stanford Medical Pion Generator (SMPG) compared to single or opposed pion beam irradiation are not only higher pion star fractions and tumour-to-entrance-region dose ratios for comparable tumour dimensions, but simpler patient immobilisation and tumour localisation. Similar benefits are expected with multiport irradiation with other charged heavy particles.

Original languageEnglish (US)
Article number004
Pages (from-to)610-619
Number of pages10
JournalPhysics in Medicine and Biology
Volume23
Issue number4
DOIs
StatePublished - 1978

Fingerprint

Mesons
Heavy Ions
Linear Energy Transfer
Neoplasms
X-Rays
Neon
Therapeutics
Helium
Neutrons
Tumor Burden
Immobilization
Ions
Radiation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

The desirability of treatment with multiple fields in charged heavy particle therapy. / Pistenma, D. A.; Li, G. C.; Bagshaw, M. A.

In: Physics in Medicine and Biology, Vol. 23, No. 4, 004, 1978, p. 610-619.

Research output: Contribution to journalArticle

Pistenma, D. A. ; Li, G. C. ; Bagshaw, M. A. / The desirability of treatment with multiple fields in charged heavy particle therapy. In: Physics in Medicine and Biology. 1978 ; Vol. 23, No. 4. pp. 610-619.
@article{3067a9e7bf9448fa98818dae11772c71,
title = "The desirability of treatment with multiple fields in charged heavy particle therapy",
abstract = "Many parallels exist in treatment planning for charged heavy particles, X-rays and neutrons. The charged particles, however, offer improved dose distributions because of their finite range. Parallel opposed, as compared to single port, irradiation with pions, helium ions and heavier ions is advantageous because of improved tumour-to-entrance-region dose ratios and more uniform distributions of the high LET radiation events throughout the tumour volumes. The clinical significance of the variations of RBE and OER with pion star fraction (or density of high LET events with the other charged heavy particles) remains to be elucidated for fractionation schemes which might be used for patient treatment. This will also be important for the evaluation of mixed heavy ion and X-ray irradiation if it is necessitated by the high RBE in the entrance region with neon and other heavy ions, or is shown to be an effective way to use heavy ions. The advantages of irradiation with the cylindrical geometry of the Stanford Medical Pion Generator (SMPG) compared to single or opposed pion beam irradiation are not only higher pion star fractions and tumour-to-entrance-region dose ratios for comparable tumour dimensions, but simpler patient immobilisation and tumour localisation. Similar benefits are expected with multiport irradiation with other charged heavy particles.",
author = "Pistenma, {D. A.} and Li, {G. C.} and Bagshaw, {M. A.}",
year = "1978",
doi = "10.1088/0031-9155/23/4/004",
language = "English (US)",
volume = "23",
pages = "610--619",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "4",

}

TY - JOUR

T1 - The desirability of treatment with multiple fields in charged heavy particle therapy

AU - Pistenma, D. A.

AU - Li, G. C.

AU - Bagshaw, M. A.

PY - 1978

Y1 - 1978

N2 - Many parallels exist in treatment planning for charged heavy particles, X-rays and neutrons. The charged particles, however, offer improved dose distributions because of their finite range. Parallel opposed, as compared to single port, irradiation with pions, helium ions and heavier ions is advantageous because of improved tumour-to-entrance-region dose ratios and more uniform distributions of the high LET radiation events throughout the tumour volumes. The clinical significance of the variations of RBE and OER with pion star fraction (or density of high LET events with the other charged heavy particles) remains to be elucidated for fractionation schemes which might be used for patient treatment. This will also be important for the evaluation of mixed heavy ion and X-ray irradiation if it is necessitated by the high RBE in the entrance region with neon and other heavy ions, or is shown to be an effective way to use heavy ions. The advantages of irradiation with the cylindrical geometry of the Stanford Medical Pion Generator (SMPG) compared to single or opposed pion beam irradiation are not only higher pion star fractions and tumour-to-entrance-region dose ratios for comparable tumour dimensions, but simpler patient immobilisation and tumour localisation. Similar benefits are expected with multiport irradiation with other charged heavy particles.

AB - Many parallels exist in treatment planning for charged heavy particles, X-rays and neutrons. The charged particles, however, offer improved dose distributions because of their finite range. Parallel opposed, as compared to single port, irradiation with pions, helium ions and heavier ions is advantageous because of improved tumour-to-entrance-region dose ratios and more uniform distributions of the high LET radiation events throughout the tumour volumes. The clinical significance of the variations of RBE and OER with pion star fraction (or density of high LET events with the other charged heavy particles) remains to be elucidated for fractionation schemes which might be used for patient treatment. This will also be important for the evaluation of mixed heavy ion and X-ray irradiation if it is necessitated by the high RBE in the entrance region with neon and other heavy ions, or is shown to be an effective way to use heavy ions. The advantages of irradiation with the cylindrical geometry of the Stanford Medical Pion Generator (SMPG) compared to single or opposed pion beam irradiation are not only higher pion star fractions and tumour-to-entrance-region dose ratios for comparable tumour dimensions, but simpler patient immobilisation and tumour localisation. Similar benefits are expected with multiport irradiation with other charged heavy particles.

UR - http://www.scopus.com/inward/record.url?scp=0018104852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018104852&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/23/4/004

DO - 10.1088/0031-9155/23/4/004

M3 - Article

C2 - 100795

AN - SCOPUS:0018104852

VL - 23

SP - 610

EP - 619

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 4

M1 - 004

ER -