The diagnostic dilemma of the 'small round cell neoplasm'. Catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma

C. P. Reynolds, R. G. Smith, E. P. Frenkel

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Small round cell neoplasms, which include neuroblastoma, Ewing's sarcoma, embryonal rhabdomyosarcoma, oat cell carcinoma, and lymphoma, are often confused with one another histologically. The advent of successful but distinct therapeutic approaches for different neoplasms has increased the need for precise diagnosis. The use of techniques ancillary to routine histologic or ultrastructural analysis allows better definition of the specific tumor type. Four cases of small cell tumor are described in which the initial working diagnosis was incorrect. The application of two diagnostic procedures for neuroblastoma was of great value in clarifying the proper diagnosis. These tests were a rapid fluorescence assay for intracellular catecholamines and a tissue culture assay for neurite outgrowth. Both of these methods are highly sensitive for neuroblastoma and distinguish neuroblastoma from other small round cell neoplasms. Their use confirmed this unsuspected diagnosis in three cases and excluded neuroblastoma in the fourth case.

Original languageEnglish (US)
Pages (from-to)2088-2094
Number of pages7
JournalCancer
Volume48
Issue number9
StatePublished - 1981

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Neuroblastoma
Catecholamines
Fluorescence
Neoplasms
Embryonal Rhabdomyosarcoma
Ewing's Sarcoma
Small Cell Carcinoma
Lymphoma
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The diagnostic dilemma of the 'small round cell neoplasm'. Catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma. / Reynolds, C. P.; Smith, R. G.; Frenkel, E. P.

In: Cancer, Vol. 48, No. 9, 1981, p. 2088-2094.

Research output: Contribution to journalArticle

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