The distribution and targeting of neuronal voltage-gated ion channels

Helen C. Lai, Lily Y. Jan

Research output: Contribution to journalReview articlepeer-review

313 Scopus citations

Abstract

Voltage-gated ion channels have to be at the right place in the right number to endow individual neurons with their specific character. Their biophysical properties together with their spatial distribution define the signalling characteristics of a neuron. Improper channel localization could cause communication defects in a neuronal network. This review covers recent studies of mechanisms for targeting voltage-gated ion channels to axons and dendrites, including trafficking, retention and endocytosis pathways for the preferential localization of particular ion channels. We also discuss how the spatial localization of these channels might contribute to the electrical excitability of neurons, and consider the need for future work in this emerging field.

Original languageEnglish (US)
Pages (from-to)548-562
Number of pages15
JournalNature Reviews Neuroscience
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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