Abstract
Advances in genetic tools and sequencing technology in the past few years have vastly expanded our understanding of the genetics of neurodevelopmental disorders. Recent high-throughput sequencing analyses of structural brain malformations, cognitive and neuropsychiatric disorders, and localized cortical dysplasias have uncovered a diverse genetic landscape beyond classic Mendelian patterns of inheritance. The underlying genetic causes of neurodevelopmental disorders implicate numerous cell biological pathways critical for normal brain development.
Original language | English (US) |
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Pages (from-to) | 195-213 |
Number of pages | 19 |
Journal | Annual Review of Genomics and Human Genetics |
Volume | 15 |
DOIs | |
State | Published - Aug 2014 |
Keywords
- autism
- brain malformations
- neurodevelopment
- somatic mutations
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)