The diverse genetic landscape of neurodevelopmental disorders

Wen F. Hu; Maria H. Chahrour; Christopher A. Walsh

doi:10.1146/annurev-genom-090413-025600

The diverse genetic landscape of neurodevelopmental disorders

Wen F. Hu, Maria H. Chahrour, Christopher A. Walsh

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Advances in genetic tools and sequencing technology in the past few years have vastly expanded our understanding of the genetics of neurodevelopmental disorders. Recent high-throughput sequencing analyses of structural brain malformations, cognitive and neuropsychiatric disorders, and localized cortical dysplasias have uncovered a diverse genetic landscape beyond classic Mendelian patterns of inheritance. The underlying genetic causes of neurodevelopmental disorders implicate numerous cell biological pathways critical for normal brain development.

Original language	English (US)
Pages (from-to)	195-213
Number of pages	19
Journal	Annual Review of Genomics and Human Genetics
Volume	15
DOIs	https://doi.org/10.1146/annurev-genom-090413-025600
State	Published - Aug 2014

Keywords

autism
brain malformations
neurodevelopment
somatic mutations

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1146/annurev-genom-090413-025600

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AB - Advances in genetic tools and sequencing technology in the past few years have vastly expanded our understanding of the genetics of neurodevelopmental disorders. Recent high-throughput sequencing analyses of structural brain malformations, cognitive and neuropsychiatric disorders, and localized cortical dysplasias have uncovered a diverse genetic landscape beyond classic Mendelian patterns of inheritance. The underlying genetic causes of neurodevelopmental disorders implicate numerous cell biological pathways critical for normal brain development.

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The diverse genetic landscape of neurodevelopmental disorders

Abstract

Keywords

ASJC Scopus subject areas

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