@article{136b9db5b7ad4023b6100db75b762dad,
title = "The Dose–Response Relationship Between Physical Activity and Cardiometabolic Health in Adolescents",
abstract = "Introduction: This study examines the dose–response relationship between moderate-to-vigorous physical activity and cardiometabolic measures in adolescents. Methods: Cross-sectional spline analyses were performed using 2003–2016 National Health and Nutrition Examination Survey data among adolescents (aged 12–19 years, N=9,195) on objectively measured (2003–2006) and self-reported (2007–2016) weekly mean minutes of moderate-to-vigorous physical activity and cardiometabolic measures (systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein, BMI, and cardiorespiratory fitness). Inflection points were determined for nonlinear relationships. Results: For objective moderate-to-vigorous physical activity, female adolescents had significant nonlinear associations with inflection points at 90 minutes/week for BMI percentile and systolic blood pressure. Male adolescents had inflection points at 150 weekly minutes of objective activity for BMI percentile and cardiorespiratory fitness. BMI percentile was about 7% lower for female and male adolescents at 150 weekly minutes of objectively measured moderate-to-vigorous physical activity than at 0 minutes. For self-reported moderate-to-vigorous physical activity, inflection points were at 375 minutes/week (diastolic blood pressure for female adolescents) and 500 minutes/week (systolic blood pressure for male adolescents). Conclusions: Among several significant dose–response relationships between physical activity and cardiometabolic health in adolescents, consistent and often nonlinear relationships were identified for BMI, with inflection points at 90–150 minutes of objective moderate-to-vigorous physical activity. Notable differences in associations and linearity were identified by sex and physical activity measure (objective or self-reported). These results support calls for any increase in physical activity among adolescents and suggest that recommendations closer to the adult guidelines of 150 weekly minutes of physical activity may be health promoting and more attainable for youth than the current recommendation of 420 weekly minutes.",
author = "Karishma Sriram and Mulder, {Hillary S.} and Frank, {Heather R.} and Santanam, {Taruni S.} and Skinner, {Asheley C.} and Perrin, {Eliana M.} and Armstrong, {Sarah C.} and Peterson, {Eric D.} and Pencina, {Michael J.} and Wong, {Charlene A.}",
note = "Funding Information: All authors—KS, HM, HF, TSS, ACS, EMP, SCA, EDP, MJP, and CAW—are responsible for the reported research and have participated in the concept and design, analysis and interpretation of data, and drafting or revising of the manuscript. All coauthors have approved the manuscript for submission to American Journal of Preventive Medicine and support its validity. All phases of this study were supported by Charlene Wong's grant from the National Heart, Lung, and Blood Institute (Grant No 1K23HL141689) at the NIH. KS, HM, and HF participated in the design, methodology, investigation, data curation, and formal analysis. ACS, EMP, SCA, EDP, MJP, and CAW participated in methodology, investigation, supervision, and funding. All authors were involved in the writing and editing of the manuscript. EDP reports support from Amarin, Amgen, Astra Zeneca, Baseline Study LLC, Bayer AG, Eli Lilly & Company, Genentech, Janssen Pharmaceutica, Merck & Co, Inc. Novartis, Reflexion Health, Regeneron, Sanofi-Aventis, and the Society of Thoracic Surgeons and consults for Abiomed, Amgen, Inc. Astra Zeneca, Baseline Study LLC, Genentech, Janssen Pharmaceutica, and Sanofi-Aventis. MJP reports past advisory consulting fee from Boehringer Ingelheim; speaking fee from Merck; and contracts to Duke University from Sanofi/Regeneron, Amgen, and BMS, not related to the submitted work. CAW reports research funded by Verily Life Science. No other financial disclosures were reported. Funding Information: All authors—KS, HM, HF, TSS, ACS , EMP, SCA , EDP, MJP, and CAW—are responsible for the reported research and have participated in the concept and design, analysis and interpretation of data, and drafting or revising of the manuscript. All coauthors have approved the manuscript for submission to American Journal of Preventive Medicine and support its validity. All phases of this study were supported by Charlene Wong's grant from the National Heart, Lung, and Blood Institute (Grant No 1K23HL141689 ) at the NIH . Publisher Copyright: {\textcopyright} 2020 American Journal of Preventive Medicine",
year = "2021",
month = jan,
doi = "10.1016/j.amepre.2020.06.027",
language = "English (US)",
volume = "60",
pages = "95--103",
journal = "American Journal of Preventive Medicine",
issn = "0749-3797",
publisher = "Elsevier Inc.",
number = "1",
}