The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection

François Leulier, Antony Rodriguez, Ranjiv S. Khush, John M. Abrams, Bruno Lemaitre

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

The Drosophila innate immune system discriminates between pathogens and responds by inducing the expression of specific antimicrobial peptide-encoding genes through distinct signaling cascades. Fungal infection activates NF-κB-like transcription factors via the Toll pathway, which also regulates innate immune responses in mammals. The pathways that mediate antibacterial defenses, however, are less defined. We have isolated loss-of-function mutations in the caspase encoding gene dredd, which block the expression of all genes that code for peptides with antibacterial activity. These mutations also render flies highly susceptible to infection by Gram-negative bacteria. Our results demonstrate that Dredd regulates antibacterial peptide gene expression, and we propose that Dredd, Immune Deficiency and the P105-like rel protein Relish define a pathway that is required to resist Gram-negative bacterial infections.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalEMBO Reports
Volume1
Issue number4
StatePublished - 2000

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Gram-Negative Bacterial Infections
Caspases
Drosophila
Gene encoding
Peptides
Gene Expression
Mutation
Mammals
Mycoses
Immune system
Pathogens
Gram-Negative Bacteria
Innate Immunity
Gene expression
Diptera
Genes
Immune System
Bacteria
Transcription Factors
Infection

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Leulier, F., Rodriguez, A., Khush, R. S., Abrams, J. M., & Lemaitre, B. (2000). The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection. EMBO Reports, 1(4), 353-358.

The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection. / Leulier, François; Rodriguez, Antony; Khush, Ranjiv S.; Abrams, John M.; Lemaitre, Bruno.

In: EMBO Reports, Vol. 1, No. 4, 2000, p. 353-358.

Research output: Contribution to journalArticle

Leulier, F, Rodriguez, A, Khush, RS, Abrams, JM & Lemaitre, B 2000, 'The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection', EMBO Reports, vol. 1, no. 4, pp. 353-358.
Leulier, François ; Rodriguez, Antony ; Khush, Ranjiv S. ; Abrams, John M. ; Lemaitre, Bruno. / The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection. In: EMBO Reports. 2000 ; Vol. 1, No. 4. pp. 353-358.
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