The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

David W. Self, Larry Stein

Research output: Contribution to journalArticle

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Abstract

The reported failure of the prototypical (but partial) D1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D1-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D1 agonist SKF 77434 and the full D1 agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D1/D2 selectivity. It is suggested that these properties, rather than partial D1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalBrain Research
Volume582
Issue number2
DOIs
StatePublished - Jun 12 1992

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Keywords

  • Dopamine D receptor
  • Reinforcement
  • Reward
  • SKF 38393
  • Self-administration
  • Stimulant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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