The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

David W. Self; Larry Stein

doi:10.1016/0006-8993(92)90155-3

The D₁ agonists SKF 82958 and SKF 77434 are self-administered by rats

David W. Self, Larry Stein

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

The reported failure of the prototypical (but partial) D₁ agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D₁-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D₁ agonist SKF 77434 and the full D₁ agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D₁/D₂ selectivity. It is suggested that these properties, rather than partial D₁ agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.

Original language	English (US)
Pages (from-to)	349-352
Number of pages	4
Journal	Brain Research
Volume	582
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)90155-3
State	Published - Jun 12 1992

Keywords

Dopamine D receptor
Reinforcement
Reward
SKF 38393
Self-administration
Stimulant

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(92)90155-3

Cite this

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title = "The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats",

abstract = "The reported failure of the prototypical (but partial) D1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D1-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D1 agonist SKF 77434 and the full D1 agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D1/D2 selectivity. It is suggested that these properties, rather than partial D1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.",

keywords = "Dopamine D receptor, Reinforcement, Reward, SKF 38393, Self-administration, Stimulant",

author = "Self, {David W.} and Larry Stein",

note = "Funding Information: This work was supported by U S. P H.S. Grants DA-05107, DA 05379 and AFOSR 89-0213 We wish to thank Dr James D. Bel-luzzi for his helpful support, and Kesten Blake and Dung Mlnh Lam for their excellent technical assistance.",

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T1 - The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

AU - Self, David W.

AU - Stein, Larry

N1 - Funding Information: This work was supported by U S. P H.S. Grants DA-05107, DA 05379 and AFOSR 89-0213 We wish to thank Dr James D. Bel-luzzi for his helpful support, and Kesten Blake and Dung Mlnh Lam for their excellent technical assistance.

PY - 1992/6/12

Y1 - 1992/6/12

N2 - The reported failure of the prototypical (but partial) D1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D1-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D1 agonist SKF 77434 and the full D1 agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D1/D2 selectivity. It is suggested that these properties, rather than partial D1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.

AB - The reported failure of the prototypical (but partial) D1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D1-mediated reinforcement. Here we demonstrate that rats will readily self-administer two SKF 38393 analogs, the partial D1 agonist SKF 77434 and the full D1 agonist SKF 82958; both compounds produce inverted U-shaped dose-response curves. When compared to the parent compound, both analogs display enhanced lipophilicity and somewhat decreased D1/D2 selectivity. It is suggested that these properties, rather than partial D1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer.

KW - Dopamine D receptor

KW - Reinforcement

KW - Reward

KW - SKF 38393

KW - Self-administration

KW - Stimulant

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