TY - JOUR
T1 - The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression
AU - Sundaresan, Vasi
AU - Roberts, Ian
AU - Bateman, Alex
AU - Bankier, Alan
AU - Sheppard, Mark
AU - Hobbs, Carl
AU - Xiong, Jeinying
AU - Minna, John
AU - Latif, Farida
AU - Lerman, Michael
AU - Rabbitts, Pamela
PY - 1998/5
Y1 - 1998/5
N2 - A new member of the NCAM family mapping to 3p12 has been isolated and predicted to be arranged in five immunoglobulin-like domains and three fibronectin-like domains which are particularly homologous to L1. There is a transmembrane domain and a long cytoplasmic region with no detectable homology to other sequences. Although less closely related to DCC, another family member, both share s loop of positively charged amino acids within the first immunoglobulin domain, unique to these two members of this very large gene family. Preliminary studies of expression in mouse embryos support an inferred role in neural development, but the observation of widespread germ expression. In adult human tissues indicates that this protein has additional functions to those performed in neural cells.
AB - A new member of the NCAM family mapping to 3p12 has been isolated and predicted to be arranged in five immunoglobulin-like domains and three fibronectin-like domains which are particularly homologous to L1. There is a transmembrane domain and a long cytoplasmic region with no detectable homology to other sequences. Although less closely related to DCC, another family member, both share s loop of positively charged amino acids within the first immunoglobulin domain, unique to these two members of this very large gene family. Preliminary studies of expression in mouse embryos support an inferred role in neural development, but the observation of widespread germ expression. In adult human tissues indicates that this protein has additional functions to those performed in neural cells.
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U2 - 10.1006/mcne.1998.0672
DO - 10.1006/mcne.1998.0672
M3 - Article
C2 - 9608531
AN - SCOPUS:0031860156
VL - 11
SP - 29
EP - 35
JO - Molecular and Cellular Neuroscience
JF - Molecular and Cellular Neuroscience
SN - 1044-7431
IS - 1-2
ER -