The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty

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59 Scopus citations

Abstract

Guo et al. provide a transcriptional cell atlas of the developing human testis during puberty, revealing dramatic developmental changes in both germ and somatic niche cell lineages. Furthermore, germ cells and Sertoli cells from testosterone-suppressed transfemale testes display partial developmental reversal, revealing critical roles for testosterone in maintaining testis maturation.

Original languageEnglish (US)
Pages (from-to)262-276.e4
JournalCell Stem Cell
Volume26
Issue number2
DOIs
StatePublished - Feb 6 2020
Externally publishedYes

Keywords

  • Leydig cell
  • peritubular myoid cell
  • puberty
  • Sertoli cell
  • single cell sequencing
  • spermatogonial stem cell
  • state 0
  • testis maturation
  • testosterone
  • transfemale

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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