The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients

Walter Peterson; Mark Feldman; Ian Taylor; Michael Bremer

doi:10.1007/BF01297125

The effect of 15(R)-15-methyl prostaglandin E₂ on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients

Walter Peterson, Mark Feldman, Ian Taylor, Michael Bremer

Internal Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The effects of 100-μg doses of 15(R)-15-methyl prostaglandin E₂ on meal-stimulated acid secretion, serum gastrin, and pancreatic polypeptide concentrations were measured in patients with duodenal ulcer. The drug given in encapsulated or unencapsulated form significantly reduced gastric acid secretion by 59% or 70%, respectively. Rises in serum gastrin and pancreatic polypeptide concentrations after the meal were significantly blunted by 15(R)-15-methyl prostaglandin E₂. This dose of prostaglandin led to no side effects and merits clinical evaluation in the treatment of peptic ulcer disease.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Digestive Diseases and Sciences
Volume	24
Issue number	5
DOIs	https://doi.org/10.1007/BF01297125
State	Published - May 1979

ASJC Scopus subject areas

Physiology
Gastroenterology

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AU - Taylor, Ian

AU - Bremer, Michael

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AB - The effects of 100-μg doses of 15(R)-15-methyl prostaglandin E2 on meal-stimulated acid secretion, serum gastrin, and pancreatic polypeptide concentrations were measured in patients with duodenal ulcer. The drug given in encapsulated or unencapsulated form significantly reduced gastric acid secretion by 59% or 70%, respectively. Rises in serum gastrin and pancreatic polypeptide concentrations after the meal were significantly blunted by 15(R)-15-methyl prostaglandin E2. This dose of prostaglandin led to no side effects and merits clinical evaluation in the treatment of peptic ulcer disease.

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The effect of 15(R)-15-methyl prostaglandin E₂ on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients

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