The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients

Walter Peterson, Mark Feldman, Ian Taylor, Michael Bremer

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The effects of 100-μg doses of 15(R)-15-methyl prostaglandin E2 on meal-stimulated acid secretion, serum gastrin, and pancreatic polypeptide concentrations were measured in patients with duodenal ulcer. The drug given in encapsulated or unencapsulated form significantly reduced gastric acid secretion by 59% or 70%, respectively. Rises in serum gastrin and pancreatic polypeptide concentrations after the meal were significantly blunted by 15(R)-15-methyl prostaglandin E2. This dose of prostaglandin led to no side effects and merits clinical evaluation in the treatment of peptic ulcer disease.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalDigestive Diseases and Sciences
Volume24
Issue number5
DOIs
StatePublished - May 1 1979

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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